传染性法氏囊病病毒反向遗传技术发展及其应用  

Development and Application of the Reverse Genetic Technologies for Infectious Bursal Disease Virus

作　　者：祁小乐[1] 王永强[1] 高立[1] 高宏雷[1] 高玉龙[1] 王笑梅[1,2] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室,哈尔滨150001 [2]江苏省动物重要疫病与人畜共患病协同创新中心,扬州225009

出　　处：《病毒学报》2015年第3期326-331,共6页Chinese Journal of Virology

基　　金：国家自然科学基金(31430087;30901083);国家973项目(2005CB523202);国家现代农业产业技术体系建设专项基金(nycytx-42-G3-01)资助

摘　　要：传染性法氏囊病病毒(Infectious bursal disease virus,IBDV)是双股双节段RNA病毒科的主要代表,其主要侵害鸡的中枢免疫器官法氏囊,引起的传染性法氏囊病(Infectious bursal disease,IBD)是危害养禽业健康发展的重要免疫抑制病。IBDV反向遗传技术诞生的近20年来,病毒拯救技术不断完善,病毒基因功能研究更为深入,而且基于此的新型疫苗的研究也有较大进展。本实验室在该领域也做了比较系统和深入的工作。本综述对IBDV致病机制和防控研究具有重要启示意义。Infectious bursal disease virus（IBDV）is an important member of the Birnaviridae family.IBDV mainly targets the bursa of Fabricius,the central immune organ of chicken,resulting in chicken infectious bursal disease（IBD）.IBD represents one of the great challenges for ongoing development of the poultry industry.Reverse genetics for IBDV emerged over twenty years ago.Since then,the technologies behind virus rescue have continually improved leading to a deep understanding of IBDV gene function and tailored vaccine development.Our lab has also been instrumental in the field of IBDV research.Here we review studies on the pathogenic mechanism and the effective prevention and control of IBD.

关 键 词：传染性法氏囊病病毒 反向遗传 细胞嗜性 毒力 疫苗 

分 类 号：S851.347.2[农业科学—预防兽医学]