骨质疏松症肾虚血瘀量化评分与性激素和血细胞参数关系研究  

Relationship among quantitative evaluation of kidney deficiency and blood stasis,sexual hormones,and parameters of the blood cells in patients with osteoporosis

作　　者：任之强[1] 赵志强[2] 晋大祥[3] 庄洪[3] 李康[2] 丁金勇[3] 马辉[1] 

机构地区：[1]广州中医药大学,广州510405 [2]河南中医学院第三附属医院骨伤科,河南郑州450008 [3]广州中医药大学第一附属医院脊柱骨科,广州510405

出　　处：《中国骨质疏松杂志》2015年第5期560-563,共4页Chinese Journal of Osteoporosis

摘　　要：目的探讨骨质疏松症患者肾虚量化评分与性激素水平、血瘀量化评分与血细胞参数间的关系,从微观水平探讨骨质疏松症肾虚血瘀量化方法的客观可靠性。方法选择2014年1月至2014年6月我院脊柱骨科确诊为骨质疏松症肾虚血瘀型女患者42例,参照李东涛等人"骨质疏松症中医基本证候定性诊断规范"、"骨质疏松症中医症状量化方法"对每位患者辨证分型并量化评分。检测骨密度(BMD)、血细胞参数(MCV、RDW-cv、MPV、PDW)、雌二醇(E2)水平。对患者肾虚量化评分和E2,血瘀证量化评分与MCV、RDW-cv、MPV、PDW进行Pearson相关分析。结果肾虚量化评分与E2水平呈显著负相关(r=-0.380,P=0.013);血瘀量化评分与MCV、MPV水平呈显著正相关(r=0.399,P=0.009;r=0.364,P=0.019),与RDWCV、PDW相关性不明显(r=0.122,P=0.443;r=0.299,P=0.057)。结论我们从微观水平上证实了骨质疏松症常见定性证候轻重程度量化评价模型能够较客观真实地反映患者肾虚血瘀程度。我们认为,骨质疏松症常见定性证候轻重程度量化评价模型操作简单,实用性较强,不但有助于临床医师简捷、准确地诊断骨质疏松症患者肾虚血瘀证型,同时还能为辨证论治时合理配伍补肾活血中药提供一定的参考,临床值得推广应用。Objective To explore the relationship among quantitative evaluation of kidney deficiency and blood stasis, sexual hormones, and parameters of blood cells in female patients with primary osteoporosis, in order to explore the reliability of quantitative evaluation of kidney deficiency and blood stasis at the micro-level.Methods Forty-two female patients with osteoporosis and kidney deficiency and blood stasis in our department from January to June 2014 were selected.They were classified and scored according to“Quantitative evaluation of the degree of traditional Chinese medicine qualitative syndromes of osteoporosis”by Li Dongtao.Bone mineral density （BMD）, blood cell parameters （MCV, RDW-cv, MPV, and PDW）, and estradiol （E2） were examined.Pearson correlation analysis was used to evaluate the relationship among quantitative evaluation of kidney deficiency and blood stasis, sexual hormones, and parameters of blood cells.Results The results showed that E2 had significant negative linear correlation with the results of quantitative evaluation of kidney deficiency （r=-0.380, P=0.013）.MCV and MPV had positive linear correlation with the results of blood stasis （r=0.399, P=0.009;r=0.364, P=0.019）.RDW-cv and PDW had no significant linear correlation with the results of blood stasis （r =0.122, P=0.443; r =0.299, P=0.057）.Conclusion We confirm that the quantitative evaluation model reflects objectively the degree of kidney deficiency and blood stasis in osteoporosis＆amp;nbsp;patients.In our opinion, the method is easy to perform and very useful in diagnose of osteoporosis with the traditional Chinese medicine syndrome type, which may be beneficial to make a better combination of herbs for the kidney nourishing and blood activating.

关 键 词：骨质疏松症 肾虚血瘀 性激素 血细胞参数 

分 类 号：R68[医药卫生—骨科学]