毛蚶提取物辅助NP化疗的增效减毒作用  

Synergism and attenuation effects of Scapharca Subcrenata Extraction on NP chemotherapy

作　　者：王作军[1] 马玉奎 贾玉萍 高清[1] 

机构地区：[1]山东省临朐县人民医院,山东临朐262600 [2]山东省药学科学院,济南250033

出　　处：《中国比较医学杂志》2015年第5期37-41,共5页Chinese Journal of Comparative Medicine

摘　　要：目的研究毛蚶提取物和NP方案化疗药物合用后有无增效和减毒作用。方法采用人肺癌A549细胞株制备裸鼠移植瘤模型,通过检测抑瘤率、体重、摄食量、血液学和血液生化学等指标,全面评价毛蚶提取物和NP化疗方案合用后的增效减毒作用。结果毛蚶提取物(125、250、500 mg/kg,i.g)与NP化疗方案合用比单用NP化疗方案抑瘤率明显提高,明显抑制化疗引起的体重减轻、摄食量减少、减轻化疗对血液系统和肝肾功能的毒副作用。结论毛蚶提取物对NP方案化疗具有明显的增效减毒作用。Objective To investigate the synergism and attenuation effects of Scapharca Subcrenata Extraction on NP chemotherapy in model mice.Methods The models of nude mice were induced with A549 cell line xenograft.The tumor inhibiting rates,body weight,food intake,hematology and blood biochemistry index were determined to evaluate the synergism and attenuation effects of Scapharca Subcrenata Extraction（125、250、500 mg/kg,i.g） on NP chemotherapy.Results Compared with NP chemotherapy group,the tumor inhibiting rates,body weight,food intake,white blood cell number were increased and glutamate pyruvate transaminase,glutamic oxalacetic transaminase and urea nitrogen were decreased markedly in NP chemotherapy plus Scapharca Subcrenata Extraction groups.Conclusion Scapharca Subcrenata Extraction has a remarkable synergism and attenuation effects on NP chemotherapy.

关 键 词：毛蚶提取物 增效减毒 抑瘤率 化疗 

分 类 号：R332[医药卫生—人体生理学]