电针对血管性痴呆模型大鼠记忆能力的影响  

A study on the effect of electroacupuncture on the memory of rats with vascular dementia

作　　者：梁慧英[1,2] 林阳阳[1] 燕铁斌[1] 廖琳[2] 董军涛[1] 

机构地区：[1]中山大学孙逸仙纪念医院康复医学科,广州510120 [2]中山市人民医院康复医学科

出　　处：《中国康复医学杂志》2015年第6期527-531,共5页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金资助项目(81171863)

摘　　要：目的:观察电针(EA)对血管性痴呆(VD)大鼠记忆能力的影响。方法:将Wistar大鼠随机分为假手术组、模型组和电针组,每组8只。假手术组暴露双侧颈总动脉,但不结扎;模型组和电针组采用双侧颈总动脉永久性结扎法建立VD大鼠模型。三组大鼠均采用柔软型大鼠固定器固定。电针组选取百会、足三里穴,接通电流,1次/d,每次留针30min,连续治疗14d;模型组与假手术组只给予固定。治疗结束后采用新事物识别实验评估大鼠的记忆能力。结果:与假手术组比较,模型组大鼠对新事物的探索指数(RI)、识别指数(DI)均降低,差异有显著性意义(P<0.05)。与模型组比较,电针组大鼠对新事物的RI、DI均升高,差异有显著性意义(P<0.05)。结论:电针可有效改善VD模型大鼠记忆能力。Objective： To observe effects of electroacupuncture（EA） on the memory of rats with vascular dementia（VD）.Method： Twenty-four Wistar rats were randomly divided into a sham-operation group, a model group and an EA group（8 in each group）. The VD rat model were performed with permanent bilateral common carotid artery occlusion in the model group and the EA group, while no occlusion of bilateral common carotid was operated in the sham- operation group. All the rats were kept in immobilization apparatus while receiving treatments. EA was applied onto＂Baihui＂（DU20） and＂Zusanli＂（ST36） acupoints in EA group for 30 min, once a day for 14 days. The sham- operation group and model group were only immobilized. After 14 days treatment, memory of the rats were evaluated by the novel object recognition test.Result： Compared with sham-operation group, recognition index（RI） and discrimination index（DI） of model group decreased with significant difference（P〈0.05）. Compared with model group, the RI and DI of EA group increased with significant difference（P〈0.05）.Conclusion： EA was helpful for improving the memory of rats with VD.

关 键 词：血管性痴呆 新事物识别实验 电针 记忆 

分 类 号：R245[医药卫生—针灸推拿学] R-332[医药卫生—中医临床基础]