门诊糖尿病患者大血管并发症情况分析  

Analysis of macrovascular complications of diabetic outpatient

作　　者：张红[1] 邱妙颜 黎衍云[2] 童文馨[1] 陈瑛[1] 车智伶 田景琰[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病研究所,上海200025 [2]上海市疾病预防控制中心糖尿病防治科,上海200336

出　　处：《内科理论与实践》2015年第2期112-115,共4页Journal of Internal Medicine Concepts & Practice

基　　金：国家自然科学基金项目(项目编号:81270935);中国糖尿病医生研究方案基金

摘　　要：目的 ：了解糖尿病患者的血糖控制及大血管并发症发生情况,并对大血管并发症相关的危险因素进行分析。方法：收集本院门诊498例糖尿病患者的临床表现、实验室检查、治疗方案及并发症发生情况,并按有无大血管并发症分组比较。采用Logistic回归分析大血管并发症相关危险因素。结果：有大血管并发症组为69例（13.9%）年龄、腰围和有高血压病史比例均显著高于无大血管并发症组（均P〈0.05）,而血糖控制情况、文化程度则不及无大血管并发症组（均P〈0.05）。对近3年新发大血管疾病的危险因素分析显示,糖尿病患者腰围和既往有高血压病史是其心脑血管疾病发生的危险因素,其比值比（OR）和95%可信区间（CI）分别为1.04（1.01~1.07）和2.09（1.10~3.97）。结论：门诊糖尿病患者大血管并发症发生率较高,为了有效预防并控制2型糖尿病患者的大血管并发症,加强血压控制、采取有效措施降低患者的腰围显得非常必要。Objective To further understand the clinical control and macrovascular complications of diabetes in out-patients. Methods A total of 498 diabetic patients were included in our analysis. The clinical manifestations, laboratory examination, diagnosis, treatment and clinical outcome were analyzed comprehensively and risk factors for macrovascular disease were detected using binary Logistic regression models. Results There were 69 patients（13.9%） with macrovascular complications. Compared with those without macrovascular disease, patients with macrovascular disease had significantly higher age, waist circumference, and history of hypertension, while control of blood glucose and educational background were poorer. Results from adjusted Logistic regression analysis showed that waist circumference and history of hypertension were associated significantly with development of macrovascular disease, with an odds ratios（95% confidence interval） 1.04（1.01-1.07） and 2.09（1.10-3.97）, respectively. Conclusions Macrovascular complications are more frequent in diabetic patients. It is necessary for diabetic patients to strengthen monitoring and controlling of blood pressure, and taking effec-tive measures to reduce waist circumference in order to prevent and control diabetes-related macrovascular disease.

关 键 词：糖尿病 大血管并发症 危险因素 

分 类 号：R587.1[医药卫生—内分泌]