海拔5070m高原移居人群用氧方案研究  

Oxygen therapy modality for people ascending to 5 070 meter altitude

作　　者：崔建华 崔宇[2] 吴佩锋 高亮 张一新 高钰琪[2] 黄缄[2] 王福领 

机构地区：[1]解放军18医院高山病研究所,新疆叶城844900 [2]第三军医大学高原军事医学系

出　　处：《西北国防医学杂志》2015年第5期311-314,共4页Medical Journal of National Defending Forces in Northwest China

基　　金：军队重大专项基金资助项目(13KJZ01);高原医学教育部重点实验室资助项目(2011JSGY05)

摘　　要：目的:探讨海拔5 070m高原移居人群的用氧方案。方法:将居住海拔5 070m高原的60名青年随机分为A组(每天上午和晚上各吸氧1h,n=20)、B组(每天上午吸氧1h,n=20)、C组(不吸氧,n=20),吸氧流量为2L/min,连续吸氧60d,比较吸氧前后慢性高原病(CMS)症状评分、睡眠质量评分、血红蛋白(Hb)浓度、HR、SaO2和6 min步行距离(6MWD)。结果:吸氧30d和60d较吸氧前:A组和B组CMS症状评分、睡眠质量评分、Hb降低,SaO2、6MWD升高,有非常显著性差异,C组Hb增高,有非常显著性差异(P<0.05或0.01);吸氧60d较吸氧30d:A组和B组CMS症状评分、睡眠质量评分降低,Hb升高,A组6MWD延长,B组SaO2升高,有显著性差异(P<0.05或0.01)。A组较B组:吸氧30d和60dCMS症状评分、睡眠质量评分均降低,吸氧60d6MWD升高,有显著性差异(P<0.05或0.01);A组较C组:吸氧30d和60dCMS症状评分、睡眠质量评分降低,SaO2、6MWD升高,有非常显著性差异(P<0.01);B组较C组:吸氧30d和60dCMS症状评分、睡眠质量评分均降低,SaO2、6MWD升高,有显著性差异(P<0.05或0.01)。结论:海拔5 070m高原每天氧疗可预防慢性高原病,改善高原睡眠质量。早晚各吸1h要优于上午吸氧1h。Objective.To investigate the rational oxygen therapy modality for people ascending to 5 070 meter plateau. Methods. Sixty young males ascending to 5 070 meter plateau for 3 months were randomly divided into three groups,group A （inhaling oxygen for 1 h in the morning and evening respectively,n= 20） ,group B （inhaling oxygen for 1 h only in the morning,n=20） ,and group C （no oxygen inhalation,n=20）. The oxygen flow rate was 2 L/rain, and the therapy lasted for 60 d. The chronic mountain sickness （CMS） symptom score,sleep quality score, hemoglobin （Hb） concentration,HR,SaO2 and 6 min walking distance were examined before and after oxygen therapy. Results. After 30 d and 60 d oxygen therapy,the CMS symptom score, sleep quality score and Hb concentration were significantly decreased,SaO2 and 6 min walking distance have a dramatic increase in group A and B （P〈0.05 or 0.01）. The Hb concentration in group C was significantly increased （P〈0.05 or 0.01）. Compared to the status after 30 d,the 60 d group had lower CMS symptom score, sleep quality score and higher Hb concentration, but higher SaO2 and 6 min walking distance （P〈0.05 or 0.01）. Group A had lower CMS symptom score and sleep quality score,but higher 6 rain walking distance compared to group B （P〈0. 05 or 0.01）. Compared to group C,group A and group B had lower CMS symptom score, sleep quality score and Hb concentration, but higher SaO2 and 6 min walking distance （P〈0.05 or 0.01）. Conclusion. The oxygen therapy for 1 to 2 h per day for peopleascending to high altitude can reduce CMS symptom, improve sleep quality, increase SaO2 and control hemoglobin concentration. The therapy for 1 h in the morning and evening respectively is better than that only in the morning.

关 键 词：高原 合理用氧 CMS 睡眠质量 6 min步行距离 

分 类 号：R594.3[医药卫生—内科学]