PAI-1基因启动子区4G/5G基因多态性与多囊卵巢综合征  

4G/5G Polymorphism in Promoter Region of PAI-1 Gene and Polycystic Ovary Syndrome

作　　者：刘元伟[1] 邓妙[1] 岑加萍 张红艳[1] 张治芬[1] 

机构地区：[1]杭州市第一人民医院妇产科,310006

出　　处：《国际妇产科学杂志》2015年第3期298-300,305,共4页Journal of International Obstetrics and Gynecology

基　　金：浙江省科技计划项目(2009C33114)

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性最常见的生殖内分泌疾病,病因迄今不明,具有高度的家族聚集性,提示遗传因素在其发病中起重要作用。纤溶酶原激活物抑制剂1(plasminogen activator inhibitor-1,PAI-1)是纤溶系统的主要生理抑制剂,大量研究表明PAI-1基因启动子区4G/5G基因多态性可通过升高血浆PAI-1水平及活性影响胰岛素的敏感性,参与胰岛素抵抗(insulin resistance,IR)的形成。IR是PCOS主要的病理生理机制,与PCOS患者肥胖、自然流产等的发生密切相关,提示PAI-1基因启动子区4G/5G基因多态性与PCOS的发生、发展可能有着密切的关系。因此,PAI-1基因启动子区4G/5G基因多态性与PCOS的相关研究也成为近年研究热点,主要涉及PCOS的发病、肥胖、IR、自然流产及远期并发心血管疾病等,但相关结论尚存争议。Polycystie ovarysyndrome（PCOS） is the most common reproductive endocrine disorders , affecting those women of childbearing age ,but its pathogenic factors is unknown so far. PCOS has a high degree of familial aggregation,indicating genetic factors play an important role in the pathogenesis. Plasminogen activator inhibitor- 1 （PAI- 1 ）is the main physiological inhibitor of fibrinolytic system, and a large number of studies have shown that 4G/5G polymorphism in promoter region of PA 1-1 gene can effect insulin sensitivity by elevating the level and activity of plasma PAI-1 ,involved in the formation of insulin resistance （IR）. IR is the mainly pathophysiology of PCOS, closely related to obesity and spontaneous abortion of PCOS, prompting that PAI-1 gene 4G/5G polymorphism may have a close relationship with the occurrence and development of PCOS. Therefore,the related research about 4G/SG polymorphism in promoter region of PAI-1 gene and PCOS has become a hot spot in recent years, mainly involved the pathogenesis,obesity,IR,spontaneous abortion and the forward complicated with cardiovascular disease of PCOS, but the conclusion is still controversial.

关 键 词：多囊卵巢综合征 纤溶酶原激活物抑制物1 胰岛素抗药性 多态现象 遗传 

分 类 号：R711.75[医药卫生—妇产科学]