靶向细胞凋亡的海洋抗肿瘤多肽药物研究进展  

Research advances of marine antitumor peptides targeting apoptosis

作　　者：林秀坤[1] 苏硕楠 

机构地区：[1]首都医科大学药理学系,北京100069

出　　处：《山东科学》2015年第3期16-22,共7页Shandong Science

基　　金：国家自然基金(81273550)

摘　　要：凋亡在肿瘤的形成和发展中具有重要功能,靶向凋亡通路已成为发展化疗药物的重要策略。海洋生物多肽是抗肿瘤药物的重要来源,并且已经发现的大多数抗肿瘤海洋多肽都可以通过诱导凋亡途径发挥抗肿瘤作用。本文针对这类海洋药物研发中存在的药物抗原性及药物来源等主要问题,综述了近年来发现的海洋多肽及其诱导细胞凋亡的信号通路。Apoptosis plays an important role in formation and development of a cancer. Targeting apoptotic pathway has become a significant strategy for developing chemotherapeutic agents. Marine peptides is an important source for antitumor drugs, most of which can exert antitumor effect by inducing apoptotic pathway. We survey recently discovered marine peptides and apoptotic signal pathway for drug antigenicity and drug sources in the development for such marine drugs.

关 键 词：海洋多肽 抗肿瘤 细胞凋亡 

分 类 号：R96[医药卫生—药理学]