Th1/Th2细胞因子网络平衡与狼疮性肾炎  

Study on the Relationship between Th1/Th2 Cytokines Network Balance and Lupus Nephritis

作　　者：米佳蕾 林慧[1] 何东初[1] 

机构地区：[1]广州军区武汉总医院中西医结合科,武汉430070

出　　处：《医学综述》2015年第12期2159-2161,共3页Medical Recapitulate

摘　　要：在机体正常的免疫系统中,Th1和Th2型细胞因子通常维持动态平衡的状态,保持机体正常的免疫功能。研究表明,狼疮性肾炎(LN)患者体内普遍存在的Th1和Th2细胞因子网络失衡是LN的主要发病机制,同时可决定疾病的活动程度,而通过调节机体内紊乱的Th1、Th2细胞因子网络,使其恢复或趋于平衡,有利于控制LN的发病及病情的进展。In the normal immune system,Th1 and Th2 cytokines are usually in a state of dynamic balance and maintain the body＇s normal immune functions. Study have found that patients with lupus nephritis（ LN） have Th1 and Th2 cytokines network imbalance,which is the main pathogenesis of the incidence of LN and could also decide the activity of the disease. Through adjusting the imbalance of Th1 and Th2 cytokines network can control the progress of the disease.

关 键 词：狼疮性肾炎 细胞因子 TH1/TH2 治疗 

分 类 号：R4[医药卫生—临床医学] Q45[生物学—生理学]