姜黄素对实验性糖尿病大鼠胃轻瘫的治疗作用  

Therapeutic Effects of Curcumin on the Gastroparesis of Experimental Diabetic Rats

作　　者：高洁[1] 李培杰[1] 吕秀清[2] 王红伟[1] 于小玲[1] 

机构地区：[1]青岛大学医学院病理生理学教研室,山东青岛266021 [2]青岛大学医学院

出　　处：《菏泽医学专科学校学报》2015年第3期4-6,共3页Journal of Heze Medical College

摘　　要：目的探讨姜黄素灌胃对糖尿病大鼠胃轻瘫的治疗作用。方法将成年雄性SD大鼠随机分为对照组、糖尿病组、姜黄素治疗2周组与姜黄素治疗4周组。分别测量各组大鼠的血糖水平、食物胃残留率和小肠推进率。结果糖尿病组与对照组相比,血糖水平和胃残留率明显升高(P<0.01);姜黄素治疗4周组与糖尿病组和姜黄素2周组相比,血糖水平和胃残留率均明显下降(P<0.05),姜黄素治疗2周组作用不明显(P>0.05);而各组之间小肠推进率无显著性差异(P>0.05)。结论姜黄素灌胃具有减轻实验性糖尿病胃轻瘫作用。Objective To explore the therapeutic effects of curcumin by lavage on the diabetic gastroparesis of rats, and provide the evidence for clinical application of curcumin to diabetic gastroparesis. Method Male SD rats were divided into four groups randomly＇. Control group, diabetic group, diabetic group treated with 2 or 4 weeks of curcumin by larage. Blood glucose, gastric residual rate and motional rate of small intestine of the rats in each group are measured respectively. Results In diabetic group, the level of blood glucose and gastric residual rate were obviously increased compared with that in control group（P〈0.01）. Compared with diabetic group or curcumin treated for 2 weeks group, the level of blood glucose and gastric residual rate were obviously reduced in the group of curcumin treated for 4 weeks（P〈0.05）. There was no obvious effects in curcumin treated for 2 weeks group（P〉0.05）. The motional rate of small intestine of the rats in each group has no significance difference（P〉0.05）. Conclusion Curcumin can alleviate experimental diabetic gastroparesis of rats.

关 键 词：姜黄素 治疗应用 灌胃 糖尿病 胃残留率 

分 类 号：R587.1[医药卫生—内分泌]