系统性红斑狼疮380例外周血淋巴细胞亚群变化及临床意义  

Changes and Clinical Significance of Peripheral Blood Lymphocyte Subsets in 380 Patients with Systemic Lupus Erythematosus

作　　者：杨宇峰[1] 朱剑[1] 茹晋丽[2] 车国柱[2] 靳志勇[2] 孙慧萍[2] 靳雪琴[2] 陈伟华[2] 李小峰[3] 

机构地区：[1]解放军总医院风湿免疫科,北京100039 [2]解放军264医院风湿免疫科,太原030001 [3]山西医科大学第二医院风湿科,太原030001

出　　处：《解放军医药杂志》2015年第5期69-72,93,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：863计划子课题(012AA02A513);山西省科技攻关项目(20120313025-7)

摘　　要：目的探讨T淋巴细胞亚群、B淋巴细胞及NK细胞的变化在系统性红斑狼疮(SLE)发生和发展中的作用。方法选取解放军264医院和山西医科大学第二医院诊治的SLE 380例及健康体检者58例,SLE患者分为稳定期组157例、轻度活动期组79例、中度活动期组82例、重度活动期组62例。检测各组外周血中T、B淋巴细胞、NK细胞、Th、Ts细胞计数及百分比,并分析SLE患者外周血淋巴细胞亚群与SLE疾病活动指数(SLEDAI)的相关性。结果活动期SLE T、Th及NK细胞计数及百分比、Ts细胞计数低于健康对照组和稳定期组,B细胞百分比高于健康对照组和稳定期组(P<0.05)。T、Th、Ts、NK细胞计数、T细胞百分比与SLEDAI评分呈负相关,B细胞百分比与SLEDAI评分呈正相关(r=-0.347、-0.311、-0.326、-0.351、-0.318、0.455,P<0.05)。结论外周血淋巴细胞亚群的变化可以为SLE患者病情评估及诊治效果提供依据。Objective To investigate the effects of T lymphocyte cell subsets,B-lymphocytes and NK cells changes in the pathogenesy and development of systemic lupus erythematosus（ SLE）. Methods A total of 380 inpatients with SLE and 58 healthy controls taking medical examination were recruited in this study,and then the SLE inpatients were divided into inactive SLE subgroup（ subgroup A,n = 157）,gentle active SLE subgroup（ subgroup B,n =79）,midrange active SLE subgroup（ subgroup C,n = 82） and severe active SLE subgroup（ subgroup D,n = 62）. The counts and percentages of T-lymphocytes,B-lymphocytes,Th,Ts and NK cells in peripheral blood were detected in the four groups. The correlations between peripheral-blood lymphocyte subsets and disease activity indexes of SLE（ SLEDAI）in SLE patients were also analyzed. Results In active subgroups,the values of counts and percentages of T,Th and NK cells and Ts cell count were significantly lower than those in control group,while B-lymphocytes percentage was significantly higher than those in control group and inactive SLE subgroup（ P〈0. 05）. The counts of T,Th,Ts,NK cells and percentage of T cell were negatively correlated with SLEDAI score,while percentage of B cell was positively correlated with SLEDAI score（ r =- 0. 347,- 0. 311,- 0. 326,- 0. 351,- 0. 318,0. 455,P〈0. 05）. Conclusion The changes of lymphocyte subsets in peripheral blood of SLE patients may be helpful in evaluating pathogenetic condition and diagnosis of the SLE.

关 键 词：免疫系统疾病 红斑狼疮 系统性 淋巴细胞亚群 

分 类 号：R593.241[医药卫生—内科学]