川芎对血管性抑郁症的脑保护作用  

The cerebral protection of Rhizoma Chuanxiong for vascular depression

作　　者：谭赛[1] 黄世敬[1] 

机构地区：[1]中国中医科学院广安门医院中药研发中心,北京硕士研究生100053

出　　处：《环球中医药》2015年第4期492-495,共4页Global Traditional Chinese Medicine

基　　金：国家自然科学基金(81072801);中央级公益性科研院所基本科研业务费专项资金(ZZ0708076);北京市中医药科技发展基金(JJ2011-84)

摘　　要：本文旨在探讨川芎对血管性抑郁症(vascular depression,VD)脑保护作用的可能机制。通过对近十几年来相关文献的检索研究发现,脑白质损伤是VD的主要病理学改变。川芎具有活血护脑抗抑郁的作用,其作用机制主要包括改善脑血流、调控凋亡基因的表达、抗自由基损伤、降低免疫炎症反应、降低氨基酸兴奋性毒性、调控核录因子кB(nuclear factor-kappa B,NF-кB)表达以及促进神经细胞修复等。目前川芎及其复方制剂在改善脑缺血引起的脑损伤方面疗效虽比较显著,但对于VD脑保护作用仍有待进一步探索研究。This paper aims to explore possible mechanisms of the cerebral protection of Rhizoma Chuanxiong for Vascular Depression（ VD）. By searching and researching literatures in recent ten years,the authors found that white matter damage is the main pathological change. Rhizoma Chuanxiong can activate blood circulation and protect the brain in anti-depression. The possible mechanisms include several aspects such as improving cerebral blood flow,regulating the expression of apoptosis gene,fighting against free radical damage,reducing the immune inflammatory response and the toxicity of excitatory amino acids,regulating the expression of NF-кB and promoting restoration of the nerve cells and so on. Although Rhizoma Chuanxiong and the compound preparations has significant effect on improving cerebral damage caused by brainischemia,the mechanisms of protective effect on VD still need further exploration.

关 键 词：川芎 血管性抑郁 脑保护 

分 类 号：R285.5[医药卫生—中药学]