红霉素肟合成进展  

Synthesis Progress of Erythromycin oxime

作　　者：潘冰[1] 申郅澄 孙志波[1] 

机构地区：[1]石药集团欧意药业有限公司,河北石家庄050051

出　　处：《煤炭与化工》2015年第6期38-42,54,共6页Coal and Chemical Industry

摘　　要：红霉素肟是第2代新型红霉素的共同中间体,应用广泛,具有广阔的市场前景。综述了红霉素肟的合成方法,并对各种方法进行了比较分析,提出针对国内外合成红霉素肟的工艺繁琐、产率较低、溶剂较多等缺点,今后应通过改变反应条件,选取恰当的游离剂,优化稳定反应体系pH,减少反应过程中酸性降解产物的生成,提高异构体的选择性等措施,找到一条红霉素肟绿色合成路线。Erythromycin oxime, which is widely used and has broad market prospects, is the common intermediate of the second new generation erythromycin. The synthesis methods of erythromycin oxime were summarized as well as various methods were analyzed and compared. Aiming at the disadvantages of cumbersome process, low yields, too many solvents and etc. of synthesis of erythromycin oxime home and abroad, by changing the reaction conditions, selecting the appropriate free agent, optimizing stable reaction system pH, reducing the production of acidic degradation products during reaction process, improving the selective measures of isomers and other measures to find a green synthesis route of erythromycin oxime.

关 键 词：大环内酯类 红霉素肟 合成 

分 类 号：TQ465.5[化学工程—制药化工]