基于血管内超声弹性成像的动脉斑块识别  

Arterial Plaques Identification Based on Intravascular Ultrasound Elasticity Imaging

作　　者：钱馨然[1,2,3] 顾天明[1] 焦阳 司法[1] 崔崤峣[1] 

机构地区：[1]中国科学院苏州生物医学工程技术研究所,苏州215163 [2]中国科学院长春光学精密机械与物理研究所,长春130033 [3]中国科学院大学,北京100049

出　　处：《生物医学工程学杂志》2015年第3期656-661,共6页Journal of Biomedical Engineering

基　　金：国家科技支撑计划资助项目(2012BAI13B02)

摘　　要：血管内超声成像技术是冠脉检查新的"金标准",超声弹性成像技术与血管内超声成像相结合,在斑块分类和检测斑块易损程度上具有重要的应用价值。本文通过建立模拟血管分层结构的仿真模型,利用血管壁在心动周期内的收缩/舒张,得到不同血压值下的血管壁组织位移分布,从而获得组织应变。通过对不同压力间隔的血管壁弹性图进行分组对比获得了在一个心动周期内成像效果最佳的血压差组合;在最佳压力差条件下,通过仿真复合不同生物力学特性的斑块模型,验证了该方法能有效地识别不同杨氏模量的斑块特性。上述研究工作不仅具有较强的理论参考价值,在临床应用中也具有重要的指导意义和应用前景。Intravascular ultrasound（IVUS）is widely used in coronary artery examination.Ultrasonic elastography combined with IVUS is very conspicuous in identifying plaque component and in detecting plaque vulnerability degree.In this study,a simulation model of the blood vessel based on finite element analysis（FEA）was established.The vessel walls generally have radial changes caused by different intravascular pressure.The signals at lower pressures were used as the pre-deformation data and the signals at higher pressure were used as the post-deformation data.Displacement distribution was constructed using the time-domain cross-correlation method,and then strain images.By comparison of elastograms under different pressures,we obtained the optimal pressure step.Furthermore,on the basis of the obtained optimize pressure step,the simulation results showed that this method could effectively distinguish characteristics between different component plaques,and could guide the later experiments and clinical applications.

关 键 词：血管内超声 弹性成像 斑块识别 应变成像 

分 类 号：R445.1[医药卫生—影像医学与核医学]