脑震荡综合征患者脑网络的度属性研究  

Study of degrees of brain network in patients with postconcussion syndrome

作　　者：彭楠 傅先明 钱若兵 李顺利 亢志强 林彬 季学兵[2] 魏祥品 牛朝诗 

机构地区：[1]安徽医科大学附属省立医院神经外科、脑功能与脑疾病安徽省重点实验室,合肥230001 [2]安徽医科大学附属省立医院影像科,合肥230001 [3]安徽医科大学第三附属医院、合肥市滨湖医院神经外科,合肥230000

出　　处：《中华神经医学杂志》2015年第6期619-622,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（30670683、30973084）;安徽省自然科学基金（11040606M167）;安徽省科技攻关计划项目（1301042201）;安徽省重点实验室绩效考核项目（1306c083028）

摘　　要：目的 应用脑网络中的度属性探讨脑震荡综合征患者脑功能的变化. 方法 选择自2013年6月至2015年3月在安徽医科大学附属省立医院就诊的脑震荡综合征患者28例为患者组,同期招募23例年龄、性别、文化程度与患者组相匹配的正常被试为对照组.采集2组成员功能MRI（fMRI）数据,应用GRETNA中网络结构模块进行数据预处理得到脑网络矩阵,网络分析模块分析得到脑网络的度属性,再将度属性的结果行统计学比较以得到有差异的脑区. 结果 患者组成员与对照相比,左侧背外侧额上回、左侧后扣带回、左侧海马、左侧缘上回、左侧角回、右侧后扣带回、右侧缘上回、右侧楔前叶、右侧颞上回、右侧丘脑的度属性差异有统计学意义（P＜0.05）.结论 脑震荡综合征患者相关脑区的度属性改变可能是脑震荡后脑功能障碍的原因之一.Objective To discuss the changes of brain functions in patients with post-concussion symptoms by evaluating degrees of brain network.Methods Twenty-eight patients with concussion for 3 months,admitted to our hospital from June 2013 to March 2015,and 23 volunteers paired in gender,age and education （healthy controls） were enrolled.The data were dealt with Network Construction,which was a part of GRETNA to obtain the Martix of brain network.Network Analysis was used to obtain degrees of brain network,and then,independent t-test was used to compare the degrees for significant brain regions.Results The degrees of brain regions with significant difference included left superior frontal gyrus,left posterior cingulate cortex,left hippocampus,left supramarginal gyrus,left angular gyrus,right posterior cingulate cortex,right supramarginal gyrus,right precuneus,right superior temporal gyrus and right thalamus as compared with those in healthy controls.Conclusions The changes of degrees in brain network may cause brain function deficits in patients with post-concussion symptoms.

关 键 词：脑震荡综合征 脑网络 度属性 功能磁共振 

分 类 号：R651.15[医药卫生—外科学]