2型糖尿病空腹胰高糖素/胰岛素比值与颈动脉内中膜厚度的相关性分析  

The Correlation between Fasting Glucagon/Insulin Ratio and Cartery Artery Intima-media Thickness in Patients with Type 2 Diabetes

作　　者：邱宗玉 余宏伟[1] 陈洋[1] 李盈盈[1] 张磊[2] 董砚虎[2] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]青岛内分泌糖尿病医院

出　　处：《潍坊医学院学报》2015年第3期223-225,共3页Acta Academiae Medicinae Weifang

摘　　要：目的：探讨2型糖尿病患者空腹胰高糖素／胰岛素（ FGLC／FINS ）比值与颈动脉内中膜厚度的相关性。方法选取2013年12月～2014年10月于青岛内分泌糖尿病医院住院的2型糖尿病患者43例，根据颈动脉内中膜厚度（CIMT）分组如下：CIMT正常组为A组（19例），CIMT 增厚组为B组（24例），另选取该院同期20例健康体检者为正常对照（ NC ）组， FINS检测采用化学发光方法， FGLC检测采用放射免疫法，计算FGLC／FINS进行比较。结果与正常对照组相比，T2DM患者FGLC／FINS显著升高（P＜0．05），T2DM患者中，CIMT增厚组较CIMT正常组FGLC／FINS显著升高（P＜0．05），多元Logistic回归分析FGLC／FINS与颈动脉内中膜增厚相关（P＜0．05）。结论 FGLC／FINS为糖尿病合并大血管并发症的危险因素之一，对预测T2DM合并大血管并发症有一定的意义。Objective To investigate the correlation between fasting glucagon/Insulin ratio and cartery artery intima-media thickness in patients with type 2 diabetes.Methods According to the intima-media thickness of carotid ar-tery,43 cases of diabetic patients in qingdao endocrinology and diabetes hospital from December 2013 to October 2014 were divided into two groups：the CIMT normal group （ group A, n=19 ） and thickening of CIMT group （ group B, n=24）.Twenty healthy people who received healthy examination were selected as control group（NC group）.FINS was de-tected by chemiluminescence method,FGLC was detected by radioimmunoassay,FGLC/FINS were calculated and com-pared.Results Compared with normal control group,T2DM was significantly increased（P〈0.05）,among T2DM pa-tients,the FGLC/FINS of CIMT thickness group was significantly increased（P〈0.05） than that of normal CIMT group. Logistic regression analysis showed that FGLC/FINS was related to the CIMT（P〈0.05）.Conclusion FGLC/FINS may be one of the risk factors of macrovascular complications for diabetic patients and of certain significance for the pre-diction of macrovascular complications of T2DM.

关 键 词：空腹胰高糖素/胰岛素比值 糖尿病 2型 颈动脉内中膜厚度 

分 类 号：R587.1[医药卫生—内分泌]