HGF与KL-6在RA-ILD患者血清中的表达水平及意义  

The Serum Levels and Clinical Significance of HGF and KL-6 in Patients of Interstitial Lung Disease with Reumatoid Arthritis

作　　者：王树刚[1] 王晓东[2] 慈春增[2] 于杰[1] 李向东[1] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊医学院附属医院免疫风湿科

出　　处：《潍坊医学院学报》2015年第3期226-228,共3页Acta Academiae Medicinae Weifang

摘　　要：目的通过检测肝细胞生长因子(HGF)和人Ⅱ型肺泡细胞表面抗原(KL-6)在类风湿关节炎合并肺间质病变(RA-ILD)患者血清中的表达水平,探讨其在RA-ILD中的意义。方法采用ELISA法检测60例RA(包括28例RA-ILD)和20例健康体检者血清HGF,KL-6的表达水平。结果 RA-ILD组中HGF的含量明显低于单纯RA组及对照组,差异有统计学意义(P<0.05);RA-ILD组中KL-6的含量明显高于单纯RA组及对照组,差异有统计学意义(P<0.05);且HGF与KL-6呈负相关关系;在RA-ILD组,HGF与疾病活动性指标DAS28评分呈负相关关系,KL-6与疾病活动性指标DAS28评分呈正相关关系。结论 HGF和KL-6可能参与RA-ILD的发生发展过程,HGF和KL-6可作为判断RA-ILD活动的指标。Objective To analyze the hepatocyte growth factor（ HGF） and human typeⅡalveolar cell sur-face antigen（ KL-6 ） serum levels and their clinical significance in the patients of interstitial lung disease with rheumatoid arthritis（ RA-ILD） .Methods The serum levels of HGF and KL-6 were detected in 60 patients with rheumatoid arthritis （ including 28 patients with interstitial lung disease） and 20 healthy individuals by means of enzyme linked immunosor-bent assay（ ELISA） .Results In patients of RA-ILD,the serum levels of HGF was lower than simple RA group and the control group,and the serum levels of KL-6 was higher than simple RA group and the control group,there were signifi-cantly statistical difference（P〈0.05）.The levels of HGF and KL-6 were negatively related;In group RA-ILD,HGF was negatively correlated with disease activity index DAS28 score,KL-6 was positively correlated with disease activity index DAS28 score.Conclusion The cytokines of HGF and KL-6 may play important roles in the development of RA-ILD;perhaps they can be seen as indexes of RA-ILD activities.

关 键 词：HGF KL-6 类风湿关节炎 肺间质病变 

分 类 号：R593.22[医药卫生—内科学]