IGF-1与糖尿病透析患者多发低转运性骨病的关系  

The Correlation of IGF-1 and Low Transport Osteodystrophy in Diabetic Hemodialysis Patients

作　　者：宋机光 赵战云[2] 李萌萌[1] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊市人民医院血液净化中心

出　　处：《潍坊医学院学报》2015年第3期229-231,共3页Acta Academiae Medicinae Weifang

摘　　要：目的研究IGF-1(胰岛素生长因子-1)与糖尿病透析患者多发低转运性骨病的关系。方法选取于潍坊市人民医院血液净化科行维持性血液透析的糖尿病患者20例(A组)和非糖尿病透析患者20例(B组),分别于透析前测定两组的血IGF-1、Ca(钙)、P(磷)、iPTH(全段甲状旁腺素)、b-ALP(骨碱性磷酸酶)、HbA1c(糖化血红蛋白)的浓度、Alb(血清白蛋白)。结果 A与B两组Ca,P浓度无统计学差异(P>0.05),但A组IGF-1,PTH,b-ALP水平低于B组(P<0.05)。A组糖化血红蛋白浓度高于B组(P<0.05)。结论在维持性血液透析患者中PTH,ALP常被用来诊断肾性骨病的敏感性指标。本试验中糖尿病透析患者较低的PTH,ALP水平,提示骨的低转运状态。同时测得糖尿病透析患者较低的血清IGF-1水平,提示IGF-1与糖尿病患者的骨低转运状态相关。Objective To study the Correlation of IGF-1 and low transport osteodystrophy in diabetic hemo-dialysis patients.Methods Twenty diabetic hemodialysis patients in blood purification center of Weifang people＆#39;s hospi-tal were selected for group A and nondiabetic hemodialysis patients for group B.The level of IGF-1,Ca,P,iPTH,b-ALP, HbA1c of this two groups were tested and compared.Results The difference of Ca,P was not statistically significant in the two group（P〉0.05）.The level of iPTH and b-ALP in group A was lower than that in group B（P〈0.05）.The level of HbA1c in group A was higher than that in group B（P〈0.05）.Conclusion The level of IGF-1 has relationship with the low transport osteodystrophy in diabetic hemodialysis patients.

关 键 词：低转运性骨病 维持性血液透析 全段甲状旁腺素 骨碱性磷酸酶 

分 类 号：R459.5[医药卫生—治疗学]