线粒体DNA的异质性  

Mitochondrial DNA Heteroplasmy

作　　者：宫健[1] 卢瑶[1] 单春华[1] 

机构地区：[1]东北林业大学,哈尔滨150040

出　　处：《中国生物化学与分子生物学报》2015年第6期575-578,共4页Chinese Journal of Biochemistry and Molecular Biology

基　　金：东北林业大学国家基础科学人才培养基金(No.J1210053);东北林业大学引进人才基金(No.015-602027)~~

摘　　要：哺乳动物线粒体DNA(mitochondrial DNA,mtDNA)位于线粒体.当细胞中mt DNA发生突变时,就会出现野生型与突变型mt DNA的共存.这种情况被称为mt DNA异质性.从mt DNA异质性的形成到在表型上引起相应的病变是一个复杂的过程.mt DNA异质性是如何形成和其在特异组织的增殖复制,mt DNA异质性的变化对个体的影响,如何提高mt DNA突变负荷检测的精度和灵敏度都是近些年的研究热点.本文对mt DNA异质性的检测、遗传、组织特异性以及其相关的疾病等方面进行了阐述.Mammal’s mitochondrial DNAs（ mtDNA） lie in the mitochondrial. When mt DNA mutations occur,the wild-type and mutant mt DNAs will be co-existent. This is called mt DNA heteroplasmy. It is a complex process from mt DNA heteroplasmy formation to the corresponding lesion of phenotype. The formation of mt DNA heteroplasmy,proliferation and replication in the specific tissue,change and effect on the individual,and detection accuracy and sensitivity of mt DNA mutation load were all research hotspots in recent years. The detection,heredity,tissue specificity,relevant diseases and some other aspects of mt DNA heteroplasmy were reviewed in this paper.

关 键 词：MTDNA 异质性 遗传 组织特异性 

分 类 号：Q31[生物学—遗传学]