核苷（酸）类似物停药后复发及长期用药的安全性  

The relapse after withdrawal of nucleos（t）ide analogs and the safety of long-term medication

作　　者：刘文华[1] 杨湛[1] 应若素[1] 

机构地区：[1]广州医科大学附属市八人民医院肝病科,510060

出　　处：《国际流行病学传染病学杂志》2015年第3期205-207,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：核苷（酸）类似物用于治疗慢性乙型肝炎已有十余年，按照指南推荐意见对经过选择的患者进行抗病毒治疗，已取得了显著的临床效果。然而，虽然按照指南推荐意见停药，甚至延长维持治疗时间，仍有相当一部分患者复发。为了减少复发，用疗程换疗效是当前的治疗策略之一，因此长期用药的安全问题需要重视。此文就核苷（酸）类似物停药后复发及长期用药安全性的研究现状进行综述。There has been a long time since the patients with chronic hepatitis B are treated with nucleos （t）ide analogues which shows significant efficacy according to the guidelines. However, when these drugs are withdrawn according to the guidelines, there is still a high relapse rate for quite a number of patients even the period of treatment is prolonged. Prolonging the period of treatment is one kind of strategy to reduce the recurrence and get the therapeutic effect. So we should pay attention to the long-term safety. The research progress on The relapse after withdrawal of nucleos（t）ide analogs and the safety of long-term medication are summarized in this paper.

关 键 词：核苷类 核苷酸类 停药 复发 安全性 

分 类 号：R512.62[医药卫生—内科学]