城市社区中老年人群高尿酸血症患病率及与血压、血糖、血脂水平的相关性调查研究  

Prevalence of Hyperuricemia and Its Correlation with Blood Pressure,Blood Glucose,Blood Lipids in Middle-aged Population in Urban Community

作　　者：范雅洁[1] 姜敏[2] 程羽萱 刘旭颖[1] 刘兰[3] 王志忠[3] 王盼盼[4] 扈学琴[4] 马玉英[4] 张金玲[5] 雷红[5] 沙丽萍[5] 何兰杰[5] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院暨生物芯片北京国家工程研究中心宁夏分中心,银川750004 [3]宁夏医科大学公共卫生学院,银川750004 [4]宁夏医科大学总医院门诊部体检办公室,银川750004 [5]宁夏医科大学总医院心脑血管病医院内分泌科,银川750002

出　　处：《宁夏医科大学学报》2015年第2期154-157,共4页Journal of Ningxia Medical University

基　　金：国家自然科学基金(81160049)

摘　　要：目的了解城市社区中老年人群高尿酸血症患病情况,并研究高尿酸血症患病率与血压、血糖、血脂的相关性,为临床疾病预防提供依据。方法采用典型抽样的流行病学调查方法,选取2011年8月-2012年12月银川市、吴忠市五个社区≥45岁的人群1295名(回汉比例为1∶1.91)进行问卷调查和体格检查,并检测血尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标。结果 1调查人群中高尿酸血症患者为142例,总患病率为10.97%。回族高尿酸血症患病率为7.87%;汉族高尿酸血症患病率为12.47%,汉族中老年人高尿酸血症患病率高于回族(χ2=6.385,P=0.011)。2男性高尿酸血症患病率17.82%,女性高尿酸血症患病率4.39%,男性患病率高于女性(χ2=59.839,P=0.000)。各年龄组男性均高于女性(P<0.05)。3回、汉族人群高血压组的高尿酸血症患病率均高于正常血压组(P<0.05)。4多因素Logistic回归分析,在P<0.05的水平,甘油三酯、高密度脂蛋白被选入多因素模型,TG是高尿酸血症的危险因素(B=0.265,OR=1.303),HDL-C是高尿酸血症的保护因子(B=-0.239,OR=0.788)。结论高尿酸血症的患病率与民族、性别、高血压、甘油三酯及高密度脂蛋白有关,预防高尿酸血症可从控制血压、降低甘油三酯、提高高密度脂蛋白水平着手。Objective To investigate the prevalence of hyperuricemia and its correlation with blood pressure, blood glucose, blood lipid in middle - aged population from urban community and to provide the basis for hyperuricemia prevention. Methods 1295 inhabitants were recruited from five urban communities in Yinchuan and Wuzhong. The ratio between Hui and Han ethnicity was 1： 1.91. The survey and the physical examination were carried out from August 2011 to December 2012. The uric acid （UA）, total cholesterol （TC）, triglyeeride （TG）, fasting blood glucose （FBG）, high density lipoprotein cholesterol （HDL- C ）, low density lipoprotein cholesterol （LDL - C ） and some other blood biochemical indexes were tested. Results ①In this study, the prevalence rate of hyperuricemia was 10.97%. The prevalence rate of hyperuricemia was 7.87% in Hui ethnicity while the prevalence rate of hyperurieemia was 12.47% in its Han counterpart. The prevalence rate of hyperuricemia was significant different between Hui and Han groups （χ2 = 6. 385, P = 0.011 ）. ②The prevalence rate of hyperuricemia was 17.82% in males while the prevalence rate was 4.39% in females. The prevalence rate of hyperuricemia in males was significantly higher than that in females （ χ2 = 59. 839, P = 0. 000 ）, also in each age group respectively （ P 〈 0.05 ）. ③ The prevalence rate of hyperuricemia was signifi tly higher in hypertension group than that in non - hypertension group both in Hui and Han （ P 〈 0.05 ）. In analysis with multivariate model, triglyceride （ P = 0.000） was an risk factor for hyperuricemia （B = 0.265, OR = 1. 303 ）, high - density lipoprotein was a protective factor （B = - 0. 239, OR = 0. 788 ）. Conclusion The prevalence rate of hyperuricemia is significantly different between ethnic populations and genders. The hyperuricemia is related to hypertension, the levels of triglyceride and high -density lipoprotein.

关 键 词：中老年 高尿酸血症 危险因素 

分 类 号：R589.7[医药卫生—内分泌]