海因改性N-季铵化壳聚糖衍生物的合成及其抗菌性能  

Synthesis and antibacterial research of hydantoin modified quaternary ammonium chitosan

作　　者：陈燕燕[1] 李明春[1] 辛梅华[1] 林意华[1] 

机构地区：[1]华侨大学材料科学与工程学院,环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《化工进展》2015年第1期188-192,233,共6页Chemical Industry and Engineering Progress

基　　金：福建省重点科技项目(2009H0030);福建省自然科学基金(2011J01312和2012J01396);科技部科技人员服务企业项目(2009GJC40030)

摘　　要：在酸性条件下,以壳聚糖与环氧季铵盐为原料反应得到水溶性良好的产物N-(2-羟丙基三甲基氯化铵)壳聚糖(HTCC),再用实验室自制的环氧海因改性,得到O-羟丙基(5,5-二甲基海因)-N-(2-羟丙基三甲基氯化铵)壳聚糖衍生物(GH-HTCC),用FTIR、1H NMR、UV-VIS和EA等对产物进行表征。抗菌实验结果表明,产物对两种菌种都有一定的抗菌活性,对金黄色葡萄球菌的抗菌活性优于大肠杆菌;GH-HTCC的抗菌活性优于HTCC,并随环氧海因取代度的增加而增强;低浓度的乙二胺四乙酸(EDTA)增强了HTCC和GH-HTCC的抗菌活性,而高浓度的EDTA在一定程度上抑制了二者的抗菌活性。Under acidic condition,N-（2-hydroxy）propyl-3-trimethyl ammonium chloride chitosan（HTCC） was synthesized by reaction of chitosan and glycidy quaternized salts. Then 3-glycidy-5,5-dimethyl hydantoin（made in our lab） was used to synthesize O-hydroxy-propyl（5,5-dimethyl hydantoin）-N-（2-hydroxy）propyl-3-trimethyl ammonium chloride chitosan（GH-HTCC）. The products were confirmed by FTIR,1H NMR,UV-VIS,EA. The results of antibacterial tests indicated antibacterial activity of these products with better antimicrobial activity against S. aureus than against E. coil. Antibacterial activity of GH-HTCC was stronger than HTCC and increased as the degree of substitution increased. A lower concentration of EDTA improved antibacterial activity of HTCC and GH-HTCC,but a higher concentration of EDTA inhibited antibacterial activity.

关 键 词：壳聚糖 季铵化 环氧海因 乙二胺四乙酸 抗菌活性 

分 类 号：O636.1[理学—高分子化学]