氧化应激反应下O-GlcNAC对骨骼肌代谢的影响  

The Role of O-GlcNAc in Skeletal Muscle Under Oxidative Stress

作　　者：张雪[1] SHI Hao 杨玉英[1] 李云龙[1] 李昌盛[1] 杨焕民[1] 计红[1] 李士泽[1] 

机构地区：[1]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319 [2]弗吉尼亚理工大学农业与生命科学学院,美国弗吉尼亚24060

出　　处：《中国畜牧杂志》2015年第13期86-90,共5页Chinese Journal of Animal Science

基　　金：国家自然科学基金项目(31272524);黑龙江省自然科学基金项目(C201103)

摘　　要：氧化应激是机体内一种不可避免的状态。正常情况下,机体内会有一系列的适应机制保护细胞免受损伤,但多种有害刺激可以打破氧化应激的平衡状态,进而对细胞信号转导系统产生影响,并导致核酸、蛋白质和脂质等大分子物质的损伤。蛋白质翻译后修饰是调控蛋白质功能及影响细胞行为的重要方式,而氧化应激会直接影响蛋白质的翻译后修饰。O-GlcNAc糖基化修饰作为一种特殊的蛋白质翻译后修饰形式,动态调节细胞信号传导途径中许多酶的功能,并且在骨骼肌中扮演着重要的角色。鉴于O-GlcNAc糖基化修饰、骨骼肌二者与氧化应激有着密切的联系。本文将重点阐述氧化应激下,O-GlcNAc糖基化修饰对骨骼肌代谢的影响。Oxidative stress is an inevitable state of the body. Oxidative stress is exog enous or endogenous ROS （reactive oxygen species, ROS） exceeds the antioxidant capacity of cells to compete fully on cell signal transduction system occurs, or further damage to nucleic acids, macromolecules such as proteins and lipids. Protein posttranslational modifications are important ways to regulate protein function and cell behavior, and oxidative stress directly influences protein post-translational modifications. O-GlcNAc glycosylation, as a special form of post- translational modification of proteins, dynamic regulates many kinds of enzyme functions in cellular signal transduction pathway and plays an important role in skeletal muscle. There fore this article focuses on the role of O-GlcNAc in skeletal muscle under Oxidative stress.

关 键 词：氧化应激 O-GLCNAC 骨骼肌 

分 类 号：S814.2[农业科学—畜牧学]