瘙痒觉相关神经通路的功能磁共振研究  

A fMRI study in brain activation evoked by mechanical stimulation induced pruritus

作　　者：徐惠[1] 辛越[2] 张秋玲[3] 孙向东[4] 朱建忠[2] 李卫红[5] 

机构地区：[1]泰山医学院放射学院,泰安271000 [2]泰山医学院附属医院影像科,泰安271000 [3]泰山医学院实验动物中心,泰安271000 [4]泰安市计量测试所 [5]泰山医学院基础医学院,泰安271000

出　　处：《中华行为医学与脑科学杂志》2015年第6期505-508,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：山东省高等学校科技计划项目（J11LF23,J09LF69）;泰安市科技发展计划项目（20132096,20131018）

摘　　要：目的 利用机械刺激足底模仿生理过程的瘙痒觉,通过功能磁共振探讨生理状态下瘙痒觉在脑内的功能区.方法 健康志愿者16人.利用毛笔笔毛轻划足底产生瘙痒觉,在3.0T MR机上进行血氧水平依赖功能磁共振扫描.采用任务态设计,SPM8（statistical parametric mapping 8,统计参数图8）软件进行数据分析,t检验,P＜0.05为差异有统计学意义.结果 瘙痒刺激引起多处脑区激活.对侧丘脑、中央旁小叶激活最强（t=5.26,5.23）;对侧中央旁小叶、中央后回和额叶激活体素数最多（分别为146,151,326）;双侧岛叶、中央前后回、丘脑、豆状核及扣带回均有不同程度的激活.结论 机械刺激足底所致瘙痒觉在脑内相关的功能区为中央后回、中央旁小叶、岛叶、中央前回和额叶。Objective To explore the functional activation cerebral areas evoked by mechanical stimulation induced pruritus perception imitating physiological process.Methods Scratching the planta gently to induce pruritus with brush pen wool in a group of 16 healthy volunteers,scanning BOLD-fMRI serials with a block design on a 3.0 T MR machine,and identifying the functional cerebral areas evoked by pruritus with SPM8 software for analysis.Student＇s t test was used to compare the difference of incidences with P〈0.05 for statistical significance.Results Several brain regions were activated by pruritus stimulus.The strongest activation evoked by pruritus was found at the contralateral thalamus and paracentral lobule（t=5.26,5.23）,the most activation volumes were found at the contralateral paracentral lobule,postcentral gyrus and prefrontal lobule（146,151 and 326 volumes）.Different degrees of activation were discovered at bilateral insula,preeentral and postcentral gyrus,thalamus,lentiform nucleus and cingulated gyrus.Conclusion The postcentral gyrus,paracentral lobule,insula,precentral gyrus and frontal lobe were the functional activation cerebral areas of pruritus perception evoked by mechanical stimulation.

关 键 词：瘙痒觉 功能磁共振 脑 

分 类 号：R445.2[医药卫生—影像医学与核医学]