健骨伸筋汤对膝关节骨性关节炎患者血液流变学影响的临床观察  

Changes of Hemorrheology and Effects of Jiangu Shenjin Soup on Osteoarthritis

作　　者：刘洪波[1] 韩平[2] 靖春颖[1] 

机构地区：[1]海南医学院中医学院,海南海口571199 [2]海南医学院附属医院,海南海口570102

出　　处：《贵阳中医学院学报》2015年第4期28-31,共4页Journal of Guiyang University of Chinese Medicine

基　　金：海南省教育厅高等学校科学研究项目;项目编号:Hjkj2011-29

摘　　要：目的:观察健骨伸筋汤对膝关节骨性关节炎患者血液流变学的影响,探讨其作用机理。方法:将诊断为膝骨关节炎的60例患者随机分为治疗组与对照组各30例,治疗组采用健骨伸筋汤口服,对照组采用双氯芬酸钠片口服。对治疗前后二组血液流变学指标进行分析比较。结果:治疗组治疗前后全血黏度、血浆黏度、红细胞聚集指数呈下降趋势,红细胞变形指数呈上升趋势,差异均有统计学意义(P<0.01);且治疗组结果与对照组比较,差异有统计学意义(P<0.05)。结论:健骨伸筋汤对膝骨关节炎血液流变学指标改善程度明显,其作用机理可能与改善血液循环,清除自由基,减少炎症刺激等作用有关。Objective： To observe the changes of hemorrheology and effects of Jiangu Shenjin Soup on osteoarthritis and explore mechanism of its action. Methods： 60 patients with osteoarthritis were randomly divided into 2 groups with 30 patients in each group： patients of treatment group were treated by Jiangu Shenjin Soup,and patients of control group were treated by Diclofenac sodium. Observe the changes of hemorrheology and effects before and after treatment. Results： The changes of hemorrheology and effects in treatment group after treatment were statistically different from those before treatment（ P 0. 01）; the changes of hemorrheology and effects in treatment group after treatment were statistically different from the control group after treatment（ P 0. 05）. Two groups had no difference before treatment（ P 0. 05）. Conclusion： Effect of Jiangu Shenjin Soup on blood rheology indicators of knee osteoarthritis patients was improved significantly. Its mechanism of action may be related to the method of improving blood circulation,scavenging free radicals,reducing inflammation and other related effects.

关 键 词：健骨伸筋汤 骨性关节炎 血液流变学 

分 类 号：R285.6[医药卫生—中药学] R274.9[医药卫生—中医学]