蛇床子素对离体肺动脉环的作用  

Effect of Osthole on Isolated Pulmonary Arteries

作　　者：何观虹[1] 滕振霞 姚丽[1] 

机构地区：[1]哈尔滨医科大学药学院生药学教研室,哈尔滨150081

出　　处：《天然产物研究与开发》2015年第6期986-989,共4页Natural Product Research and Development

基　　金：国家自然基金青年项目(81302764);高等学校博士学科点专项科研基金新教师类资助课题(20122307120011);黑龙江省自然基金(QC2011C021);黑龙江省大学生创新创业训练项目(2013)

摘　　要：为了研究蛇床子素对离体肺动脉的作用,本研究游离人及健康SD大鼠的肺动脉血管和SD大鼠的肠系膜动脉血管,剪成长约3 mm的血管环,观察不同浓度的蛇床子素对人和大鼠离体肺动脉以及大鼠肠系膜动脉收缩的作用。结果表明蛇床子素（10-9~10-5mol/L）对人和大鼠苯肾上腺素预收缩的肺动脉具有浓度依赖性的舒张作用,对大鼠肠系膜动脉和正常的肺动脉无舒张作用。证实蛇床子素可舒张人和大鼠离体肺动脉环,其舒张作用具有浓度依赖性和组织特异性。To study the effect of osthole on isolated pulmonary arteries by using force-electricity transducers,pulmonary arteries isolated from human beings and healthy SD rats and mesenteric arteries from SD rats were cut into rings（ about3 mm in length） and observed the response of artery contraction to different doses of osthole. The results showed that osthole（ 10-9-10-5mol / L） relaxed phenylephrine-precontrated isolated pulmonary arteries of both human beings and rats in a dose-dependent manner,but not mesenteric arteries and normal pulmonary arteries. Therefore,osthole relaxed human and rat isolated pulmonary arteries in a dose-dependent manner and was tissue specific.

关 键 词：蛇床子素 肺动脉高压 肺动脉环 

分 类 号：R93[医药卫生—生药学]