中剂量普萘洛尔治疗婴儿血管瘤临床疗效评价  

Treatment of infantile hemangioma with middle- dose propranolol

作　　者：张毅[1] 余静[1] 谢坚[1] 刘蓉[1] 管利荣[1] 赵荣香[1] 胡煜[1] 

机构地区：[1]绵阳市中心医院儿科,四川绵阳621000

出　　处：《医药论坛杂志》2015年第6期20-21,共2页Journal of Medical Forum

基　　金：四川省卫生厅科研基金资助(100320)

摘　　要：目的 评价普萘洛尔治疗婴儿血管瘤的临床疗效和安全性,初步探讨适合该项治疗的最佳年龄、疗程和血管瘤类型。方法 对2010年4月至2012年6月间绵阳市中心医院儿科收治的105例婴儿血管瘤患者口服普萘洛尔（2.0mg/（kg·d）,连续服用3-9个月）,治疗期间每月随访一次,连续观察血管瘤大小、质地及颜色变化3-14个月,按照Achauer4级评分法对疗效进行评价,将Ⅲ、Ⅳ级评价为临床治疗有效,治疗过程中及时处理药物不良反应。结果 随访3-14个月,疗效评定为Ⅳ级（优）者59例（56.1%）,Ⅲ级（好）21例（20.0%）,Ⅱ级（中）16例（15.2%）,Ⅰ级（差）9例（8.6%）。深部血管瘤的疗效显著优于浅表型血管瘤（P〈0.05）。结论 口服普萘洛尔治疗婴儿增生期血管瘤近期疗效显著,普萘洛尔治疗婴儿血管瘤有良好的临床应用前景。Objective To evaluate the results of propranolol for the treatment of infantile hemangioma. Methods Oral propranolol was administered to 105 infants with heamngiom at a dose of 2. 0mg per kilogram of body weight per day. The patients were revisited once a month. The changes of the tumor size texture and colour were monitored and recorded at a regular interval. The adverse effects after medication were observed and managed accordingly. The short - term results were evaluated using a 4 Scales system. Results Among the 105 patients treated, scale Ⅱ （moderate） in 16 patients （ 15.2% ）, scale Ⅲ （ good ） in 21 patients （ 20. 0% ） and cale Ⅳ （ excellent ） in 59 patients （ 56. 1% ）. Statistica analysis showed that the treatme it is different （P 〈 0.05 ）. Conclusions Oral propranolol is effective method for the treatment of infantile heamngioma. The results were excellent and the side effects minimal.

关 键 词：婴儿血管瘤 普萘洛尔 临床疗效 

分 类 号：R725.4[医药卫生—儿科]