辐射法制备布洛芬金属分子印迹聚合膜  

Preparation of ibuprofen's metal-complexing imprinted polymer membrane via radiation polymerization

作　　者：郭聪[1] 王兵[1] 皇甫风云[2] 单娟娟[1] 

机构地区：[1]天津工业大学环境与化学工程学院中空纤维膜材料与膜过程省部共建国家重点实验室培育基地,天津300160 [2]天津工业大学天津工大纺织助剂有限公司,天津300160

出　　处：《功能材料》2015年第14期14134-14139,共6页Journal of Functional Materials

基　　金：天津市自然科学基金资助项目(13JCQNJC02600)

摘　　要：以消炎镇痛药(S)-布洛芬与Cu2+配合物为模板分子,以甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,聚砜膜为多孔支撑层,利用辐射引发聚合制备了Cu2+配位分子印迹复合膜。通过紫外光谱研究发现,(S)-布洛芬、Cu2+和甲基丙烯酸形成了配位比为1∶2∶2的3元配合物。通过扫描电镜及渗透实验发现聚砜基膜固含量为17%时,修饰后印迹膜形态及性能最好。同时,通过选择渗透实验发现,印迹膜对其手性对称物(R)-布洛芬及结构类似物酮洛芬渗透选择性较差。Using(S)-ibuprofen-Cu2+complex as template,methacrylic acid as the functional monomer,ethylene glycol dimethacrylate(EGDMA)as the cross-linker and poly-sulfone membrane as the porous support layer,(S)-ibuprofen-Cu2+metal-complexing imprinted polymer membrane were prepared via radiation polymerization.Through the UV-Vis spectrum study,(S)-ibuprofen,Cu2+and methyl acrylic acid were formed ternary complexes with the ratio 2∶1∶2.By scanning electron microscopy(SEM)and permeation experiment,when the solid content of poly-sulfone membrane was 17%,the morphology and performance of imprinted membrane were the best after modification.At the same time,by selective permeation experiment,it was found that compared to its chiral symmetry compound(R)-ibuprofen and structural analogues ketoprofen,the imprinted membrane only showed excellent permeability to(S)-ibuprofen.

关 键 词：金属配位 分子印迹膜 布洛芬 CU^2+ 

分 类 号：O63[理学—高分子化学]