口蹄疫病毒样颗粒研究进展  

Advance of Virus-like Particles of Foot-and-Mouth Disease

作　　者：魏婕[1] 魏玉荣[1] 易忠[1] 

机构地区：[1]新疆畜牧科学院兽医研究所,新疆乌鲁木齐830000

出　　处：《草食家畜》2015年第4期6-10,共5页Grass-Feeding Livestock

基　　金：新疆维吾尔自治区自然基金青年基金项目(2012211B55)

摘　　要：病毒样颗粒(VLP)具有与真实病毒粒子大小相似的结构,能引起免疫应答但不具有感染性。口蹄疫病毒是无囊膜的RNA病毒,其结构蛋白可组装成VLP,且具有良好的免疫原性。本文对口蹄疫病毒VLP的免疫机制、表达系统及应用、口蹄疫病毒VLP作为抗原在诊断和疫苗中的应用进行了综述。Virus-like particles (VLPs)share the similar structure and immunogenicitywith natural virus particles except absent of viral genes, but still are able to induce the antigen-antibody response, thus could beuse as a promising platform for vaccines.The foot-and-mouth disease virus (FMDV) belongs to the Picornaviridae family and consists of non-enveloped particles that contain a positive-sense, single-stranded RNA of approximate 8.5 kb. The P1-2A precursor is processed by viral protease 3C to produce the structural proteins VP0, VP1 and VP3. These proteins could self-assemble to formempty capsid-like particles. This review will focus on the immunologic mechanism,expression system and application of FMDV VLPs as antigen in vaccine and diagnosis.

关 键 词：蹄疫病毒 病毒样颗粒 疫苗 

分 类 号：S852.65[农业科学—基础兽医学]