培哚普利与尼群地平对原发性高血压患者血管内皮依赖性舒张功能的影响  

Effect of Quinapril Versus Nitrendipine on Endothelium-dependent Vascular Relaxing Function in Patients with Systemic Hypertension

作　　者：杨静茹[1] 范瑞云[2] 宋艳霞[2] 

机构地区：[1]中国人民解放军第266医院特诊科,河北承德067000 [2]中国人民解放军第272医院急诊康复中心,天津300020

出　　处：《河北医学》2015年第11期1840-1842,共3页Hebei Medicine

摘　　要：目的：比较培哚普利和尼群地平对高血压患者血管内皮功能的影响,更好地指导临床用药。方法：选择高血压患者46例,随机分为培哚普利治疗组（P组,n=23）及尼群地平组（N组,n=23）,运用无创超声检查技术,观察用药前后肱动脉内皮依赖性舒张功能（FMD）的变化。结果：两组服药后血压下降的幅度无明显差异（培哚普利组12±14mm Hg,尼群地平组10±12mm Hg）,培哚普利组,流量介导的扩张反应（FMD）增加明显（1.7±2.8-5.8±4.7）,而尼群地平无增加（1.1±3.3-1.1±3.9）,两组FMD的变化有明显统计学意义（P〈0.01）。结论：培多普利能明显改善高血压患者的内皮功能,尼群地平无此作用。Objective： To investigate whether the ACE inhibitor quinapril or calcium-channel blocker nitrendipine improves the FMD of the brachial artery in hypertensive patients. Method： Forty-six hypertensive patients were randomized quinapril group and nitrendipine group. Then non-invasive ultrasonic examination was operated to observe the brachial artery endothelium-dependent diastolic function of pre-and post- treatment. Result： The reduction in blood pressure was not significantly different between the 2 groups（the mean arterial pressure decreased by 12±14mmHg in the quinapril group. Whereas it decreased by 10±12mmHg in the nitrendipine group）.The flow-mediated dilation of the radial artery was significantly increased in the quinapril group （ 1.7±2.8 to 5.8 ±4.7 ） , However, the FMD was impaired after nitrendipine treatment（ 1.1±3.3 to 1.1±3.9）,the FMD was significantly greater in the quinalril group than that in the nitrendipine group after dueg administration （ P 〈0.01 ）. Conclusion： Quinapril improves endothelial dysfunction in hypertensive patients,whereas nitrendipine does not.

关 键 词：培多普利 尼群地平 高血压 内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病]