贞芪扶正胶囊联合高效抗逆转录病毒疗法对艾滋病患者Thl/Th2、Tcl/Tc2和CD4^＋T淋巴细胞的影响  

Effects ofZhenqi-Fuzhengcapsule combined with highly active antiretroviral therapy the Thl/Th2, Tcl/Tc2, and CD4^＋T lymphocytes in patients with advanced AIDS

作　　者：陈仁芳[1] 戴亚萍[2] 杨琦恩[1] 陆宇红[1] 蒋亦明[1] 

机构地区：[1]江苏省无锡市第五人民医院感染科,214005 [2]江苏省无锡市第五人民医院检验科,214005

出　　处：《国际中医中药杂志》2015年第7期594-597,共4页International Journal of Traditional Chinese Medicine

基　　金：江苏省无锡市科技局资助项目（CSZ01045）

摘　　要：目的：探讨贞芪扶正胶囊联合高效抗逆转录病毒疗法（highly active antiretroviral therapy， HAART）对艾滋病患者Th1/Th2、Tc1/Tc2和CD4^＋T淋巴细胞的影响。方法本研究为随机对照研究。将符合纳入标准的70例艾滋病患者按随机数字表法分为2组各35例，对照组采用HAART治疗，给予拉米夫定＋齐多夫定或司他夫定＋奈韦拉平或依非韦伦，治疗组给予贞芪扶正胶囊联合 HAART 治疗，疗程均为24周。采用流式细胞仪检测所有患者治疗前、后血清Thl、Th2、Tcl、Tc2、CD4^＋T淋巴细胞的变化。结果治疗后，治疗组Thl/Th2[（6.27±0.70）比（5.39±0.64），P＜0.05]、Tcl/Tc2[（10.70±0.68）比（10.16±0.85），P＜0.05]比值显著高于对照组，差异均有统计学意义。治疗组[（289.2±101.5）个/ml比（121.1±77.5）个/ml，P＜0.01]和对照组[（231.6±97.6）个/ml比（118.9±76.2）个/ml，P＜0.01]CD4^＋T淋巴细胞计数均较治疗前增加，2组治疗后比较差异有统计学意义（P＜0.05）。结论贞芪扶正胶囊联合HAART可改善艾滋病患者Thl/Th2、Tcl/Tc2平衡，提高CD4^＋T细胞计数。Objective To investigate the effects ofZhenqi-Fuzheng capsule combined with highly active antiretroviral therapy （HAART） the Thl/Th2, Tcl/Tc2, and CD4^＋ T lymphocytes in patients with advanced AIDS.Methods A total of 70 patients with advanced AIDS were randomly divided into a treatment group and a control group, with 35 patients in each group. The treatment group was treated withZhenqi-Fuzheng capsule combined with HAART, while the control group was treated with HAART only. The patients in both groups were treated for 24 weeks. The Thl, Th2, Tcl, Tc2 and CD4^＋ T lymphocytes in peripheral blood were detected by flow cytometer.Results After treatment, the ratios of Th1/Th2 （6.27 ± 0.70vs. 5.39 ± 0.64;P〈0.05） and Tcl/Tc2 （10.70 ± 0.68vs. 10.16 ± 0.85;P〈0.05） in the treatment group showed significantly higher than those in the control group. The CD4^＋T lymphocytes after the treatment in both groups showed significantly increased than that before the treatment （treatment group： 289.2 ± 101.5/mlvs. 121.1 ± 77.5/ml,P〈0.01; control group： 231.6 ± 97.6/mlvs. 118.9 ± 76.2/ml,P〈0.01）. The CD4^＋T lymphocytes in the treatment group showed significantly increased than that in the control group after the treatment （P〈0.05）.ConclusionsZhenqi-Fuzhengcapsule combined with HAART may regulate the Thl/Th2 and Tcl/Tc2, and increase the CD4^＋ T lymphocytes in patients with advanced AIDS.

关 键 词：获得性免疫缺陷综合征 T-淋巴细胞亚群 CD4-阳性T淋巴细胞 TH1细胞 Th2细胞 抗逆转录病毒治疗 高效 贞芪扶正胶囊 

分 类 号：R512.91[医药卫生—内科学]