C5a受体与肾脏疾病关系的研究进展  

Progress on Relationship between C5a Receptor and Nephropathy

作　　者：张泽英[1,2] 刘东旭[1] 

机构地区：[1]湖北大学生命科学学院,湖北武汉430062 [2]武汉生物工程学院食品工程系,湖北武汉430015

出　　处：《动物医学进展》2015年第7期78-81,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31070776)

摘　　要：补体活化产物C5a是炎症反应趋化因子,具有过敏毒素样作用和强趋化作用,在炎症反应过程中起着重要的作用。C5a的作用主要通过与C5a受体的结合来实现。研究表明在多种肾脏疾病中均可引肾脏细胞中C5a受体的表达增加,从不同层面阻断C5a与C5a受体的相互作用可降低肾脏损伤。随着C5a受体功能、信号传递途径及与肾脏疾病关系的不断深入研究,C5a受体有望成为一个有效的治疗靶点,在炎症性疾病治疗过程中发挥作用。论文综述了C5a受体的结构、信号传导途径及与肾脏炎症性疾病的关系,有助于为肾脏炎症性疾病的治疗提供参考。Complement activation product C5a, which is one of inflammatory chemokines, has anaphylatoxin function and chemotaxis. CSa plays an important role in inflammatory response, which is realized by its combination with C5a receptor. Research showed that expression of CSa receptor in nephrocyte is increased in various nephropathy. Blocking the interaction of CSa and C5a receptor can relieve kidney injury. With the deeply research of C5a receptor function, signaling pathway and its relationship to nephropathy, C5a receptor is expected to become a good therapeutic target. The review focused on the structure, signaling pathway of C5a receptor and its relationship with nephropathy, which will be helpful to provide a scientific basisi for the treatment of nephropathy.

关 键 词：C5A C5A受体 信号传导 肾脏疾病 

分 类 号：S852.4[农业科学—基础兽医学]