弗氏柠檬酸杆菌对动物和人致病性研究进展  

Progress on Citrobacter freundii Pathogenicity in Animals and Humans

作　　者：薛巧[1] 赵战勤[1] 刘会胜[1] 薛云 董发明[1] 

机构地区：[1]河南科技大学动物科技学院动物病原微生物实验室,河南洛阳471003 [2]医学技术与工程学院微生物检验实验室,河南洛阳471003

出　　处：《动物医学进展》2015年第7期81-85,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31302106);河南省科技攻关计划项目(132300410279)

摘　　要：弗氏柠檬酸杆菌在自然界广泛分布,是一种典型的人-畜-鱼共患病条件性致病菌,一般情况下不引起动物和人发病。近年来,陆续有报道弗氏柠檬酸杆菌强毒株也能引起动物败血症甚至急性死亡,且对水产动物的致病报道较多。人类可因弗氏柠檬酸杆菌感染而发生腹泻、食物中毒和继发感染。弗氏柠檬酸杆菌引起动物和人感染时有携带如β-内酰胺酶等新型耐药基因的可能,且发现有cfa、ST和SLT等多种毒力因子。综合研究表明弗氏柠檬酸杆菌可能是一种尚未被人们充分认识的病原菌,且有危害加重的趋势。因此,在动物和人类疾病防治中不能忽视弗氏柠檬酸杆菌。论文主要阐述了弗氏柠檬酸杆菌对动物和人的致病性方面取得的进展,旨在引起研究者对弗氏柠檬酸杆菌致病性的重视,并展望了弗氏柠檬酸杆菌未来研究的方向。Citrobacter freundii, which distributes extensively in the nature, is a kind of typical human-domestic animal-fish opportunistic pathogens and generally can not cause animal and human disease. In recent years, strong virulence strains frequently cause septicemia and acute death oF animals, especially for aquatic animals. Citrobacter freundii can also cause human diarrhea, food poisoning and secondary infection. Citrobacter freundii is likely to harbor the β-lactamase genes and the virulence genes of cfa, ST, SLT while infecting animals and humans. In a word, humans have no full knowledge on pathogenicity of Citrobacter freundii and the pathogenicity is getting greater. As a result, the control and prevention of animal and human disease can not ignore Citrobacter freundii. The review summarized the progress on Citrobacter freundii and focused on the pathogenicity in animals and humans in recent years. On this ba- sis, more practical problems and prospects about Citrobacter freundii were also discussed. The main objective of this article was to draw researchers＂ attention on the pathogenicity of Citrobacter freundii.

关 键 词：弗氏柠檬酸杆菌 动物 人 致病性 耐药 

分 类 号：R913.7[医药卫生—药学]