猴B病毒研究进展  

Progress on Monkey B Virus

作　　者：杨燕飞[1,2] 周洁 高诚 

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]上海实验动物研究中心,上海201203

出　　处：《动物医学进展》2015年第7期94-99,共6页Progress In Veterinary Medicine

基　　金：上海市科委科技创新行动计划项目(13140900600)

摘　　要：猴B病毒(MBV)是生物安全4级病原,其自然宿主是猴,在猴群中广泛存在,猴感染后无症状或出现轻微的疱疹,而人感染后可出现神经症状或致死性的进行性脑脊髓炎,死亡率较高。MBV可在猴和人的感觉神经节潜伏,间歇性复活排毒,常导致检测结果假阴性;另外,MBV与HSV、SA8等有广泛的抗原交叉性,常导致检测结果假阳性。因此,MBV对检测时间及检测方法的敏感性、特异性有较高要求。目前没有针对MBV的有效疫苗和药物,全面了解MBV并采取适当的预防措施才能有效地避免MBV感染。Monkey B virus（MBV） is one of BSL-4 zoonotic agents. It naturally infects conventional population of macaques, which may show asymptomatic or slight herpes lesions. While it transmits to humans, it can cause neurological symptoms or progressive encephalomyelitis with high mortality. MBV can establish latent infection in sensory ganglia, then periodic reactive and shedding, often lead to false negative testing result. Moreover, there is extensive antigenic cross-reactivity among MBV and HSV and SA8 and so on, it usually causes false positive detection results. Therefore, it＇s a challenge to the test time and the sensitivity and specificity of detection methods. There is no specific vaccine and antiviral drugs. The comprehensive understanding of MBV and taking appropriate preventive measures is the most important. This will help you avoid the infection of MBV.

关 键 词：猴B病毒 潜伏感染 检测 预防 

分 类 号：S855.3[农业科学—临床兽医学]