联合检测胃肠疾病患者血清胃蛋白酶原Ⅰ和胃蛋白酶原Ⅱ水平的临床意义  

The clinical significance of combined detection of serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in gastrointestinal diseases patients

作　　者：黄雪梅[1] 

机构地区：[1]四川省遂宁市中心医院检验科,四川遂宁629000

出　　处：《实用医院临床杂志》2015年第4期93-94,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨血清胃蛋白酶原I（PGI）和胃蛋白酶原II（PGII）在胃肠道疾病诊断中的临床意义。方法收集我院2014年2～8月的胃肠道疾病患者血清650例（胃肠道疾病组）,同期体检者血清1544例（体检组）,其他住院和门诊患者血清824例（其他组）,采用时间分辨荧光免疫法定量检测分析三组PGI、PGII水平,并对结果进行分析。结果体验组PGI升高200例,降低32例;PGII升高88例,PGI/PGII比值降低74例。胃肠道疾病组PGI升高202例,降低33例;PGII升高113例,PGI/PGII比值降低54例;824例其它住院和门诊患者血清中,PGI升高139例,降低32例;PGII升高71例,PGI/PGII比值降低35例。胃肠道疾病组患者的PGI和PGII阳性率高于体验组和其他组（P〈0.05）。结论血清PGI和PGII可作为胃肠镜检查前的第一线筛查方式,尤其是老年患者。Objective To investigate the values of pepsinogen I（PGI） and pepsinogen II（PGII） in the diagnosis of gastrointestinal diseases.Methods Six hundred and fifty patients with gastrointestinal diseases,1544 healthy subjects and 824 non-gastrointestinal disease patients in our hospital from February to August 2014 were included in the study.Serum levels of PGI and PGII were detected by using a time-resolved fluorescence method and the results were statistically analyzed.Results Among all the healthy individuals,increased PGI was found in 200 subjects and 88 had elevated PGⅡ.Decreased PGⅠ and ratio of PGⅠ/PGⅡ were found in 32 and74 health controls,respectively.Among the 650 patients with gastrointestinal diseases,increased PGⅠ was found in 202 patients,and increased PGⅡ in 88 patients.Decreased PGⅠ and ratio of PGⅠ/PGⅡ were found in 33 and 54 patients,respectively.Among the 824 patients with non-gastrointestinal diseases,PGⅠ was elevated in 139 patients and PGⅡ was decreased in 32 patients.PG Ⅰ was decreased in 32 patients and the ratio of PGⅠ/PGⅡ was decreased in 35 patients.The positive rates of PGI and PGII in the patients with gastrointestinal disease were higher than that in the healthy subjects,and the patients with non-gastrointestinal disease.Conclusion PGI and PGII have some clinical values in the diagnosis of gastrointestinal diseases.It may be used as the first line of screening method before gastrointestinal endoscopy.

关 键 词：胃蛋白酶原I 胃蛋白酶原II 胃肠道疾病 

分 类 号：R446.62[医药卫生—诊断学]