17例人微小病毒B19肝炎患者临床特点分析  

Clinical characteristics of patients with human parvovirus B19 infection:An analysis of 17 cases

作　　者：苏少慧[1] 胡义亭[1] 侯洪涛[1] 刘娜[1] 王玉珍[1] 

机构地区：[1]河北省人民医院消化科,石家庄市050051

出　　处：《实用肝脏病杂志》2015年第4期364-366,共3页Journal of Practical Hepatology

摘　　要：目的探讨人微小病毒B19肝炎患者的临床特征。方法对17例感染人微小病毒B19患者的病例资料进行回顾性分析,总结肝损害的特点和临床特征。结果 17例人微小病毒B19肝炎患者均有发热(100%),有全身乏力14例(82.4%)、关节、肌肉痛9例(52.9%)、咽痛6例(35.3%)、食欲减退11例(64.7%)、皮疹5例(29.4%)、脾肿大12例(70.6%),肝肿大7例(41.2%)、淋巴结肿大3例(17.6%)、黄疸5例(29.4%);除血ALT和AST升高外,伴有羟丁酸脱氢酶、乳酸脱氢酶、腺苷脱氨酶升高和淋巴细胞百分比升高;起病急,临床表现复杂,但多呈急性自限性过程,肝功能恢复较快,预后较好。结论对不明原因肝损害同时伴有上述特征者,除常规筛查常见的嗜肝病毒外,及时检测血清抗人微小病毒B19抗体Ig M,能帮助明确一部分患者的病因。Objective To summarize the clinical characteristics of patients with human parvovirus B19 in- fection. Methods The clinical materials in 17 patients with human parvovirus （HPV） B19 infection was retro- spectively summarized,and the clinical features,laboratory findings and radiologic imaging were analyzed. Results The predominant symptoms and signs of patients in this series were：fever （100.0%）,general fatigue （82.4%）, arthralgia/myalgia （52.9%）, pharyngalgia （ 17.4% ）, anorexia （64.7%）, rash （ 17.3% ）, splenomegaly （70.6%）, hepatomegaly （41.2%）,lymphadenectasis （17.6%） and jaundice （17.3%）;The laboratory findings showed elevated serum alanine aminotransferase and aspartate transferase,lactate dehydrogenase,hydroxyhutyrate dehydrogenase and adenosine deaminase levels,and higher lymphocyte counts; Hepatic injury caused by HPV B19 infection had fea- tures of acute onset and complicated clinical manifestations, but with a self-limited illness course. The recovery of liver function was rapid and the prognosis was relatively good. Conclusion The patients who have unex- plained hepatic injury should have a prompt detection of serum anti-HPV B19 IgM,especially in those with nega- tive serum hepatitis A,B, C and E virus markers.

关 键 词：人微小病毒B19 肝损害 临床特征 

分 类 号：R512.6[医药卫生—内科学]