氯沙坦钾对慢性肾小球肾炎患者血清尿酸的影响  

Effect of losartan potassium on uric acid in chronic glomerulonephritis

作　　者：李雪[1] 张蓓茹[1] 杨旭[1] 李德天[1] 

机构地区：[1]中国医科大学附属盛京医院肾脏内科,沈阳110004

出　　处：《实用药物与临床》2015年第6期669-672,共4页Practical Pharmacy and Clinical Remedies

基　　金：卫生公益性行业科研专项合作项目(201002010)

摘　　要：目的评价氯沙坦钾、缬沙坦、替米沙坦治疗慢性肾小球肾炎的疗效及对尿酸的影响。方法选择2013年5月至2014年5月于我院住院的148例原发性慢性肾小球肾炎患者。按照治疗方法不同,分为氯沙坦钾组(54例)、缬沙坦组(48例)、替米沙坦组(46例)。观察对比治疗3个月后患者血清尿酸、血压、24 h尿蛋白定量、血清白蛋白及肾功能变化。结果治疗3个月后,氯沙坦钾组患者血清尿酸由(378.18±108.58)降至(325.91±99.04),治疗前后比较差异有统计学意义(P<0.01);治疗前,缬沙坦组、替米沙坦组的血清尿酸分别为(370.75±72.70)、(356.59±91.21),治疗后为(379.08±82.128)、(354.85±59.16),治疗前后比较差异无统计学意义(P>0.05)。氯沙坦钾组治疗后24 h尿蛋白定量、血压、血清白蛋白及肾功能和缬沙坦组及替米沙坦组相似,差异无统计学意义(P>0.05)。结论氯沙坦钾亚除具有降低尿蛋白及降压作用外,还具有良好的降尿酸作用。Objective To compare the effects of losartan potassium,valsartan and telmisartan on uric acid of patients with chronic glomerulonephritis. Methods One hundred and forty-eight patients with primary chronic glomerulonephritis from May 2013 to May 2014 in our hospital were retrospectively analyzed. The patients were divided into 3groups according to the different treatment. Patients in group L,group V and group T received losartan potassium tables,valsartan tablets and telmisartan tablets respectively for 3 months. The changes of uric acid,blood pressure,24 h urine protein,albumin and renal function of the patients in 3 groups were compared. Results After 3 months of treatment,the uric acid of group L decreased from（ 378. 18 ± 108. 58） to（ 325. 91 ± 99. 04）,there was significant difference（ P〈0. 01）,but no significant difference was found in group V and group T. There was no significant difference in 24 h urine protein,blood pressure,albumin and renal function among the 3 groups（ P〉0. 05）. Conclusion Losartan potassium can not only reduce urine protein and blood pressure,but also have good effect on reducing uric acid.

关 键 词：氯沙坦钾 慢性肾小球肾炎 尿酸 24h尿蛋白 血压 

分 类 号：R692.31[医药卫生—泌尿科学]