活血祛瘀洗剂药效学实验研究  

Experimental study on the lotion for promoting blood circulation and removing blood stasis in pharmacodynamics

作　　者：刘冬平[1] 李蜀平[1] 廖磊[1] 刘魁英[1] 刘洋[1] 战嘉怡[1] 

机构地区：[1]北京市卫生局临床药学研究所中药新药及制剂研发中心,北京100035

出　　处：《北京中医药》2015年第6期495-497,共3页Beijing Journal of Traditional Chinese Medicine

基　　金：北京市中医药科技发展基金资助项目(JJ2012-30)

摘　　要：目的观察活血祛瘀洗剂作用,为临床应用提供实验依据。方法对大鼠急性血瘀模型预防性应用活血祛瘀洗剂,检测其对模型大鼠全血黏度、血浆黏度的影响;对小鼠微循环障碍模型预防性应用活血祛瘀洗剂,检测其对模型小鼠耳廓微循环的改善情况;对小鼠疼痛模型预防性应用活血祛瘀洗剂,观察活血祛瘀洗剂的镇痛作用。结果与急性血瘀模型组比较,活血祛瘀洗剂0.32、0.64 g/m L剂量组大鼠全血黏度明显降低(P<0.05,P<0.01);与微循环障碍模型组比较,活血祛瘀洗剂0.40、0.80 g/m L剂量组小鼠耳廓微循环改善(P<0.05);活血祛瘀洗剂0.40、0.80 g/m L剂量组对化学刺激和热刺激引起的疼痛均有一定的镇痛作用(P<0.05)。结论活血祛瘀洗剂具有一定的活血化瘀和镇痛作用。Objective To observe the effects of lotion for promoting blood circulation and removing blood stasis so as to provide experimental evidence for the clinical application. Methods The rat models with acute blood stasis were applied with the lotion for promoting blood circulation and removing blood stasis for prevention, its influence on the whole blood viscosity and plasma viscosity were detected; the rat models with microcirculation dysfunction were applied with the lotion for prevention, and the improvement of microcirculation in auricle were observed; the rat models with pain were applied for prevention with the lotion, and its analgesic effect was observed. Results Compared with the acute blood stasis model group, the whole blood viscosity in the lotion group with the dosage of 0. 32, 0. 64 g/mL was reduced significantly （P 〈 0.05, P 〈 0.01 ） ; compared with the microcirculation dysfunction model group, the microcirculation of auricle in lotion group with the dosage of 0. 40, 0. 80 g/mL was improved （ P 〈 0.05 ） ; a certain analgesic effect for pain caused by the chemical and heat stimulation was shown in the lotion group with the dosage of 0. 40, 0. 80 g/mL （P 〈 0. 05）. Conclusion Lotion for promoting blood circulation and removing blood stasis has certain effect in promoting blood circulation and removing blood stasis and also has an analgesic action.

关 键 词：活血祛瘀洗剂 活血化瘀 微循环障碍 镇痛 大鼠 小鼠 

分 类 号：R285.5[医药卫生—中药学]