局部外用虎杖膏治疗钙剂渗漏致组织损伤的实验研究  

Experimental study on topical external application of polygonum cuspidatum cream in treatment of patients with tissue damage induced by calcium exteravasation

作　　者：张咏梅[1] 王玲[1] 黄桥[1] 

机构地区：[1]遵义医学院附属医院

出　　处：《护理研究（上旬版）》2015年第7期2322-2324,共3页Chinese Nursing Researsh

基　　金：贵州省卫生厅科学技术基金项目;编号:gzwkj2013-1-061

摘　　要：[目的]探讨局部外用虎杖膏对钙剂渗漏致组织损伤的疗效。[方法]选取新西兰成年大白兔12只,制作钙剂渗漏损伤模型后分为虎杖膏组、硫酸镁组和空白组,每组4只。虎杖膏组制模后即刻在局部外涂虎杖膏,硫酸镁组用33%硫酸镁湿纱布外敷,持续5d;空白组不作处理。用药期间每天肉眼观察局部肿胀面积;第5天用药后取局部组织做病理切片,光镜下观察炎症反应及严重程度。[结果]虎杖膏组、硫酸镁组用药5d内肉眼观察肿胀面积与空白组比较,差异均有统计学意义(P<0.05),且自第2天起虎杖膏组消肿效果优于硫酸镁组(P<0.05);用药第5天后虎杖膏组镜下组织学分析显示炎细胞浸润、水肿、充血及坏死严重程度与空白组比较差异有统计学意义(P<0.016 7),且与硫酸镁组比较,在炎细胞浸润、水肿及坏死程度上也有差异(P<0.016 7)。[结论]静脉输注钙剂渗漏致组织损伤后外用虎杖膏和硫酸镁均可降低局部炎症反应和组织损伤程度,且虎杖膏在减轻渗漏局部组织炎性浸润与组织坏死方面作用更明显。Objective：To define the curative effect of topical external application with polygonum cuspidatum cream for preventing and reducing tissue damage induced by calcium extravasation in patients.Methods：A total of 1 2 New Zealand adult rabbits were selected,and after they were made as calcium extravasation inj ury model and were divided into polygonum cuspidatum cream group,magnesium sulfate group and blank group,4 rabbits in each.Embrocation with polygonum cuspidatum cream was carried out for rabbits model in polygonum cuspi-datum cream group,33% magnesium sulfate wet gauze was used for external application in magnesium group lasting for 5 days;the rabbits model in blank group didn’t had any treatment.During medication,the daily local swelling area was observed by the naked eyes.On the fifth day after the medication,the local tissue biopsy was taken and to observe inflammatory reaction and severity under light microscope.Results：There was statistically significant difference in the naked eye swelling area in 5 days after treatment（P〈0.05）.And starting from the second day the swelling effect of polygonum cuspidatum cream group was better than that in magnesium group （P〈0.05）.After medication for 5 days,the microscopic histological analysis showed that there was statistically significant difference in the inflammatory cell infiltration,edema,congestion and necrosis severity between both groups （P〈0.016 7）,and compared with the magnesium sulfate group,there was statistically significant differ-ence in inflammatory cell infiltration,edema and necrosis（P〈0.016 7）.Conclusion：After intravenous calcium extravasation induced tissue inj ury,the topical external application with polygonum cuspidatum cream and mag-nesium sulfate can reduce the local inflammatory response and the extent of tissue damage.And polygonum cus-pidatum cream has more obvious effect in reducing and preventing the inflammatory infiltration and necrosis in extravasation of local tissue.

关 键 词：钙剂 渗漏 组织损伤 虎杖膏 硫酸镁 局部外用 实验研究 

分 类 号：R471[医药卫生—护理学]