重症监护室医院感染危险因素的Meta分析  

Meta-analysis of the risk factors on hospital infection in intensive care unit

作　　者：林建潮[1] 王灵红[1] 周新萍[1] 

机构地区：[1]绍兴第二医院

出　　处：《中国医院统计》2015年第3期170-172,共3页Chinese Journal of Hospital Statistics

摘　　要：目的：综合评价重症监护室（ ICU）患者发生医院感染的危险因素，为ICU医院感染的预防控制决策提供参考依据。方法应用Meta分析方法对国内11篇有关ICU医院感染的主要危险因素的病例-对照研究结果进行定量综合分析；采用Review Manager 5.2进行一致性检验及合并OR值和95%置信区间的计算。结果各因素合并OR值分别为：年龄≥60岁OR=1.73（95%CI：1.29~2.31）；住院天数≥7天OR=7.43（95%CI：2.02~27.34）；气管切开/插管OR=4.37（95%CI：1.74~10.96）；留置导尿OR=3.83（95%CI：1.89~7.79）；深静脉置管OR=3.58（95%CI：1.99~6.42）；抗生素使用≥3种OR=2.51（95%CI：1.45~4.36）；昏迷OR=3.87（95%CI：2.06~7.26）；免疫制剂OR=2.42（95%CI：1.39~4.23）。结论影响重症监护室医院感染的危险因素为年龄、住院天数、气管切开/插管、留置导尿、深静脉置管、抗生素使用、昏迷及免疫制剂的使用，为ICU医院感染的预防提供了科学依据。Objective To provide evidence for decision-making on hospital infection prevention through studying the main risk factors related to the incidence of hospital infection. Methods Meta-analysis was used to comprehensively and quanti-tatively evaluate the 11 case-control studies on risk factors of hospital infection. With Review Manager 5. 2 we carried out consis-tency check, pooled OR and calculated 95% confidence interval. Results The pooled odds ratio values were 1. 73（95%CI：1. 29~2. 31）for patients aged 60 and above, 7. 43（95%CI：2. 02~27. 34）for those with 7 hospitalization days and above, 4. 37 （95%CI：1. 74~10. 96）for those with tracheostomy/intubation, 3. 83（95%CI：1. 89~7. 79）for those with catheterization, 3. 58 （95%CI：1. 99~6. 42）for those with deep venous catheter, 2. 51（95%CI：1. 45~4. 36）for those with 3 types of antibiotic use and above, 3. 87（95%CI：2. 06~7. 26）for those in coma, and 2. 42（95%CI：1. 39~4. 23）for those with immune agents. Con-clusion The major risk factors influencing the incidence of hospital infection in China were aging, days in hospital, tracheosto-my/intubation, catheterization, deep venous catheter, types of antibiotic use, coma, and immune agents, and the results could provide scientific basis for hospital infection intervention.

关 键 词：重症监护室 医院感染 危险因素 META分析 

分 类 号：R19[医药卫生—卫生事业管理]