军事应激对部队官兵血清和胃黏膜白细胞介素6水平的影响  

Impact of military stress on levels of interleukin-6 in serum and gastric mucosa of servicemen

作　　者：高娟[1] 郑国荣[1] 王艳[1] 李旻[1] 徐维田[1] 熊毅敏[1] 

机构地区：[1]广州军区武汉总医院消化内科,武汉430070

出　　处：《军事医学》2015年第5期345-347,共3页Military Medical Sciences

摘　　要：目的探讨军事演习前后部队官兵血清和胃黏膜中白细胞介素6(interleukin-6,IL-6)的水平及其意义。方法分别采用酶联免疫吸附和免疫组化的方法检测某部60名官兵军事演习前后血清和胃黏膜中IL-6的水平。结果军事演习后官兵血清中IL-6的含量明显高于演习前(P<0.01);IL-6在胃黏膜组织中主要表达于部分间质细胞及腺上皮细胞的胞浆中,演习后其表达明显高于演习前(P<0.01)。结论 IL-6可能中介了军事应激所致的胃黏膜病变。在军事应激早期检测该细胞因子的含量有助于评估发生胃黏膜病变的可能性及严重程度。Objective To investigate the levels of IL-6 in serum and gastric mucosa of servicemen before and after mili-tary maneuver and their significance .Methods The level of serum IL-6 in 60 servicemen was studied by enzyme-linked immunosorbent assay .The expression of IL-6 in gastric mucosa from the 60 servicemen was detected by immunochemical staining.Results The level of IL-6 in serum of servicemen after military maneuver was significantly higher than that before military maneuver （P〈0.01）.IL-6 was found to be expressed in the cytoplasm of epithelioglandular cells and also in the cytoplasm of mesenchymal cells .The expression of IL-6 in gastirc mucosa was significantly stronger after military maneuver than before military maneuver （P〈0.01）.Conclusion IL-6 might be involved in the development of pathological changes in gastric mucosa caused by military stress in troops .Examination of the level of IL-6 in the early stage of military stress might help assess the chance of gastric mucosa lesion and its severity .

关 键 词：白细胞介素6 军事应激 血清 胃黏膜病变 

分 类 号：R823[医药卫生—临床医学]