40～59岁女性体力活动水平与端粒体相对长度的相关性  

Correlation Between Physical Activity and Telomere Length in 40-59 Years Old Women

作　　者：王艳[1] 王正珍[1] 

机构地区：[1]北京体育大学运动康复系,北京100084

出　　处：《北京体育大学学报》2015年第6期55-59,88,共6页Journal of Beijing Sport University

基　　金：国家"十二五"科技支撑计划课题(编号:2012BAK21B02);高等学校博士学科点专项科研基金项目(编号:20131112110002)

摘　　要：目的：测量、评价40～59岁女性体力活动（PA）水平,探讨PA水平与人体抗衰老标志——端粒体相对长度（T/S）的相关性。方法：筛选71名40～59岁女性,通过7 d的加速度计佩戴,测试、评价PA水平,并计算出1周从事中等强度PA（MPA）的时间,将其分为PA活跃组和PA不足组。采用实时荧光定量PCR法测人体外周血白细胞T/S值,分析PA水平与T/S值之间的相关性。结果：40～59岁女性有52.11%未达到我国最低体力活动推荐量,即PA不足;在40～49岁、50～59岁年龄组,年龄与T/S值呈负相关（1.80±0.78 vs.1.44±0.65;r=-0.364）;40～49岁、50～59岁MPA的时间与T/S值之间呈正相关（r=0.474 vs.r=0.268）;在同一年龄段,超重肥胖组中年女性的T/S值均明显小于正常体重组的（1.58±0.69 vs.1.77±0.71;1.34±0.60 vs.1.57±0.97）。结论：本研究中,40～59岁女性有52.11%未达到我国最低体力活动推荐量;此推荐量能够延缓40～49岁女性T/S值因增龄引起的下降,对人体抗衰老有积极的促进作用;PA水平达到我国推荐量的50～59岁女性并未显示出T/S值因增龄引起的下降;在同年龄组,超重肥胖组的T/S值相对较小。Purpose： The Purpose of this study was to measure and evaluate the physical activities（ PA） of 40- 59 years old women,and detect the relationship between PA level and telomere length which is a body＇s anti-aging maker. Methods： Seventy-one 40- 59 years old women were recruited and required to wear accelerometer for seven days,and then were divided into PA activity group and PA inactivity group. Their PA level was tested,and their moderate-intensity PA（ MPA） per week was calculated. Also their relative length of telomere（ T / S） of blood leukocyte was tested by PCR,and the correlation between T / S and PA was explored. Results： 1） There are52. 11% 40- 59 years old women don＇t have enough PA while 72. 73% obese 40- 59 years old women haven＇t enough PA. 2） There is negative correlation between age and T / S（ r =- 0. 364）. 3） There are positive correlations between MPA and T / S in 40- 49 years old women（ r = 0. 268） and 50- 59 years old women（ r = 0. 474）.4） T / S is shorter in obese women than in normal women（ 1. 42 ± 0. 70 vs. 1. 72 ± 0. 69）. Conclusions： Keeping a high level of PA can delay the shortening of the telomere length caused by aging,which can promote anti-aging of human. The aging degree of overweight and obese middle-aged women is higher than that of normal weight women with the same ages.

关 键 词：中年女性 体力活动 端粒体长度 抗衰老 肥胖 

分 类 号：G804.2[文化科学—运动人体科学]