子宫内膜微创预处理在多囊卵巢综合征不孕患者促排卵治疗中的疗效观察  

Effect of endometrium minimally invasive pretreatment on non -pregnant PCOS patients who are on ovulation induction treatment

作　　者：魏敏敏[1] 韩艳荣[1] 

机构地区：[1]寿光市妇幼保健院生殖内分泌科,山东省寿光262700

出　　处：《中国基层医药》2015年第13期1924-1926,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山东省潍坊市卫生局计划课题（2014058）

摘　　要：目的：观察子宫内膜微创预处理在多囊卵巢综合征（PCOS）不孕患者促排卵治疗中的疗效。方法选择66例在自然月经周期的晚卵泡期超声提示子宫内膜回声紊乱及异常增厚的 PCOS 育龄期不孕症患者，按数字表法随机分为研究组与对照组各33例。患者均用屈罗酮炔雌醇片治疗3-6个周期后，用氯米芬（CC）促排卵治疗，研究组于月经来潮3-5 d 内，用一次性宫腔组织吸引管对子宫内膜行微创预处理，对照组不行内膜微创预处理，两组患者均给予雌激素及黄体酮治疗，结合 B 超监测卵泡及子宫内膜厚度。结果研究组子宫内膜厚度（8．78±±1．56）mm，妊娠率36．36％，流产率16．67％，手术操作时无明显疼痛不适，无感染发生；对照组内膜厚度（6．32±0．74）mm，妊娠率24．24％，流产率12．50％。两组内膜厚度、妊娠率差异有统计学意义（t ＝8．184，χ2＝4．60，均 P ＜0．05）。结论一次性宫腔组织吸引管对子宫内膜进行微创预处理，可增加子宫内膜厚度，提高妊娠率，不增加早期流产率，且有易于操作、方便、创伤小、痛苦小、易接受等优点。Objective To observe the therapeutic effect of endometrium minimally invasive pretreatment on non -pregnant PCOS patients who are on ovulation induction treatment.Methods According to the digital meter method,divided 66 non -pregnant PCOS patients who were with abnormal endometrial echoes or abnormal thickening by ultrasound in follicular phase in natural periodwith into testing group（33 cases）and control group（33 cases）.All patients were treated with drospirenone and ethinylestradiol tablets treatment for 3 to 6 cycles,and then with clomi-phene citrate（CC）for induction of ovulation.In the testing group,endometrium microresecting was given by disposa-ble uterine cavity tissue suction tube device within 3 -5days after menstrual onset.Patients in the control group were not performed with endometrium microresecting.All patients of the two groups were given estrogen and progesteroneas well as detection of ovarian folicle and endom etrium with B -modeult rasonography.Results Intimal thickness in the testing group was（8.78 ±1.56）mm,the pregnancy rate was 36.36% and the abortion rate was 16.67%,there was no obvious pain and unwell during the operation and the patients were free from infection.Intimal thickness in the testing group was（6.32 ±0.74）mm,the pregnancy rate was 24.24% and the abortion rate was 12.50%.There were significant differences between the two groups of endometrial thickness,pregnancy rate（t =8.184,χ2 =4.60,all P 〈0.05）.Conclusion Endometrium microresecting by endometrial sampling device can increase the endometrium, thickness and the pregnancy rate,and at the same time it doesnot increase the rate of early spontaneous abortion.And it is easy to perate,convenient,less trauma,less pain,easy to acceptand and some other advantages,it has better clini-cal application value,so it deserves to be applied in basic hospital.

关 键 词：子宫内膜异常 子宫内膜微创术 多囊卵巢综合征 促排卵 

分 类 号：R713[医药卫生—妇产科学]