一氧化碳中毒后迟发性脑病患者血清中白细胞介素4、白细胞介素10、干扰素γ、转换生长因子β1的水平变化及意义  

Changes and meaning of Serum IL -4,IL -10,IFN -gamma,TGF -beta 1 level in patients with delayed en-cephalopathy after carbon monoxide poisoning

作　　者：周志天 陆明岳 

机构地区：[1]舟山医院门诊内科,浙江省舟山316000 [2]舟山医院急诊科,浙江省舟山316000

出　　处：《中国基层医药》2015年第13期2028-2030,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨一氧化碳中毒后迟发性脑病（DEACMP）患者血清中白细胞介素4（IL-4）、白细胞介素10（IL-10）、干扰素γ（IFN-γ）、转换生长因子β1（TGF-β1）的水平变化及意义。方法选择40例 DEACMP患者为 A 组，将40例 DEACMP 患者分为轻度认知功能障碍12例，中度认知功能障碍20例，重度认知功能障碍8例。选择40例急性一氧化碳中毒（ACMP）患者为 B 组；另选择同期健康者40名为健康对照组。检测统计受试者血清 IL-4、IL-10、IFN-γ、TGF-β1含量。结果A 组和 B 组血清 IL-4水平为（26．32±4．28）ng／L 和（29．78±4．39）ng／L，低于健康对照组的（40．78±6．82）ng／L（P ＜0．01），B 组血清 IL-10水平为（35．16±6.72）ng／L，高于 A 组的（25．06±5．21）ng／L 和健康对照组的（26．92±5．37）ng／L（P ＜0．01），A 组和 B 组血清 IFN-γ水平为（27．16±9．29）ng／L 和（19．06±8.31）ng／L，高于健康对照组的（12．98±8．15）ng／L（P ＜0.01），且 A 组 IFN-γ水平高于 B 组（P ＜0．01），A 组血清 TGF-β1水平为（32．08±5．62）ng／L，低于 B 组的（52．75±7．61）ng／L 和对照组的（41．08±6．97）ng／L（P ＜0.01）。随着 DEACMP 患者认知障碍的加重，IL-4、IL-10、TGF-β1水平呈下降趋势，IFN-γ水平呈上升趋势（P ＜0．01）。结论DEACMP 患者血清中 IL-4、IL-10、IFN-γ、TGF-β等指标存在异常表达，血清 IL-4、IL-10、IFN-γ、TGF-β1等水平与 DEACMP 患者认知功能障碍程度有关。DEACMP 的发病及进展可能与神经免疫损伤有关。Objective To study changes and meaning of serum IL -4,IL -10,IFN -gamma,TGF -beta 1 level in patients with delayed encephalopathy after carbon monoxide poisoning.Methods From January 2011 and June 2014 in our hospital,40 cases of DEACMP patients were selected as group A;the 40 patients with DEACMP was divided into 12 cases of mild cognitive dysfunction,mild cognitive dysfunction in 20 cases,8 cases of severe cognitive dysfunction.40 cases with acute carbon monoxide poisoning （ACMP）patients were selected as group B;40 cases of healthy subjects were selected as healthy controls.Serum interleukin 4 and interleukin 10（IL -4）（IL -10）,interfer-on gamma （IFN -gamma）,conversion,growth factor beta 1 （TGF -beta 1）content were tested.Results In Group A and group B serum IL -4 levels were lower than that of healthy controls （P 〈0.01）,and serum levels of IL -10 in group B were higher than that in group A and healthy controls （P 〈0.01）,serum level of IFN -gamma in group A and group B was higher than the healthy controls （P 〈0.01）,and in group A IFN -gamma levels were higher than group B （P 〈0.01）,while in group A serum TGF -beta 1 level was lower than B group and the control group （P 〈0.01）,and in group B TGF -beta 1 level was higher than the control group （P 〈0.01）;With cognitive impairment aggravating of DEACMP patients,IL -4,IL -10,TGF -beta 1 levels were on the decline,and IFN -gamma level was increasing （P 〈0.01）.Conclusion DEACMP patients serum and cerebrospinal fluid of IL -4,IL -10,IFN -gam-ma,TGF -beta measures such as abnormal expression,showed that the onset of DEACMP may be related to neural immune injury.Serum IL -4,IL -10,IFN -gamma and TGF -beta of DEACMP patients exists abnormal expression Serum IL -4,IL -10,IFN -gamma and TGF -beta levels are also related to the degree of cognitive impairment of DEACMP patients.The onset and progress of DEACMP may be associated with neural immune injury.

关 键 词：一氧化碳中毒 迟发性脑病 免疫功能损伤 机制 

分 类 号：R595.1[医药卫生—内科学] R747.9[医药卫生—临床医学]