虫草素在Aβ1-42寡聚体诱导AD模型大鼠神经元损伤中的作用  

The effects of Cordycepin on rat's neuron injury of AD model induced by Aβ1-42 oligomer

作　　者：郑衍芳[1] 吕文昌[1] 孙田静 郑丽萍[1] 张文权[1] 宋志语 周袁 

机构地区：[1]遵义医学院珠海校区生理学教研室,广东珠海519041

出　　处：《黑龙江医药科学》2015年第3期8-10,13,共4页Heilongjiang Medicine and Pharmacy

基　　金：国家自然科学基金资助项目;编号:31040075

摘　　要：虫草素为天然中药材冬虫夏草和人工培养蛹虫草的有效成分。近年来研究表明,虫草素具有抗肿瘤,抗衰老,抗白血病等药理作用。阿尔茨海默病是一种神经系统退行性疾病。可溶性Aβ1-42寡聚体具有神经细胞毒性且是阿尔茨海默病发病的关键因素。本文探讨了虫草素在Aβ1-42寡聚体诱导AD模型大鼠神经元损伤中的作用。Cordycepin is an effective component for natural Chinese herbal medicine Cordyceps sinensis and artificial cultivation of Cordyceps militaris.Recent studies showed that cordycepin has anti-tumor,anti-aging,anti white blood pharmacological effects.Alzheimer＇s disease is a degenerative disease of nervous system.Soluble A beta 1-42 oligomers has nerve cell toxicity,and is a key factor in the pathogenesis of Alzheimer＇s disease.In this paper,we investigate the effects of Cordycepin on rat＇s neuron injury of AD model induced by Aβ1-42 oligomer.

关 键 词：虫草素 Aβ1-42寡聚体 AD模型 神经元 

分 类 号：G642.41[文化科学—高等教育学]