尿MA、α1-MG、β2-MG联合血Cys-C检测对于儿童支原体肺炎早期肾脏损害的诊断意义  

The effects of the test of urine MA、α1-MG、β2-MG and Cys-C on early kidney injury related with Mycoplasma Pneumonia(MP) among children

作　　者：王丽敏[1] 王超[1] 韩小唯 王淑静[1] 

机构地区：[1]佳木斯大学附属第一医院儿科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2015年第3期116-117,119,共3页Heilongjiang Medicine and Pharmacy

基　　金：佳木斯大学科研项目;编号:L2012-047

摘　　要：目的:探讨支原体肺炎患儿尿微量白蛋白(micoalbuminuria,MA)、β2-微球蛋白(β2-microglobulin,β2-MG)、α1-微球蛋白(α1-microglobulin,α1-MG)、血清胱抑素-C(Cys-C)变化,发现支原体肺炎患儿早期肾脏损害,指导临床治疗,进一步关注早期肾脏损害。方法:入选164例支原体肺炎患儿,采用胶体金免疫层析技术检测尿MA,采用双光镜比浊法检测尿液α1-MG及β2-MG,采用免疫比浊法检测血清胱抑素-C,并与186例正常对照儿童进行比较。结果:支原体肺炎组:MA、BUN及Cr异常率分别为2.1%0.6%,1.04%。Cys-C异常率3.2%,α1-MG异常率22.9%,β2-MG异常率78.1%,其中,β2-MG及α1-MG感染组及健康组对比具有统计学意义(P<0.05)。结论:支原体肺炎患儿合并早期肾脏损害,在MA、Cys-C、Cr及BUN未出现异常时,α1-MG及β2-MG异常改变提示支原体肺炎引起早期肾脏损害。Objective： To investigate the change of the level of micoalbuminuria（MA）,β2-microglobulin（β2-MG）,α1-microglobulin（α1-MG） and Cys-C in children with Mycoplasma Pneumonia（MP） so as to find early kidney injury for clinic treatment.Methods： The level of urine MA was detected using Colloidal gold immune.Urine α1-MG and β2-MG was evaluated by double light turbidimetr assay.Cys-C was tested by Immunoturbidimetric Assays.Results： The abnormal rate of MA,BUN and Cr in infection group were 2.1% 0.6% and1.04% respectively.The abnormal rate of Cys-C was 3.2%,22.9% in α1-MG,78.1% in β2-MG.There were significant differences between β2-MG infection group and control group（P〈0.05）.Conclusions： Children with mycoplasma pneumonia complicated with early renal damage.The abnormal of α1-MG and β2-MG were earlier than MA,Cys-C,Cr and BUN.We can diagnosis early kidney injury with the levels of β2-MG.

关 键 词：儿童支原体肺炎 早期肾脏损害 尿微量白蛋白 β2-微球蛋白 Α1-微球蛋白 血清胱抑素-C 

分 类 号：R725.6[医药卫生—儿科]