多索茶碱联合舒利迭治疗小儿支气管哮喘66例临床观察  

Clinical observation on doxofylline combined with seretide in treating 66 cases of children bronchial asthma

作　　者：黄晓玲[1] 刘佳[1] 张小芳[1] 

机构地区：[1]四川省内江市第一人民医院儿科,641000

出　　处：《检验医学与临床》2015年第13期1883-1884,共2页Laboratory Medicine and Clinic

摘　　要：目的通过研究多索茶碱联合舒利迭(沙美特罗替卡松)治疗小儿支气管哮喘的临床效果,为临床治疗提供更多方案。方法选择2012年2月至2014年2月该院入院治疗的132例小儿支气管哮喘患儿,分为对照组和试验组,每组66例。对照组患儿单独给予舒利迭治疗,试验组患儿采用多索茶碱联合舒利迭治疗。结果两组患儿咳嗽、喘息、肺部啰音以及气喘等临床症状的消失时间明显试验组少于对照组,差异有统计学意义(P<0.05);两组患儿第1秒用力呼气量(FEV1)、用力肺活量(FVC)和肺活量(VC)的水平均明显升高,并且试验组升高的更明显,两组比较差异有统计学意义(P<0.05);经过治疗,试验组的临床总有效率是93.9%,明显高于对照组的78.8%,差异有统计学意义(P<0.05),试验组患儿不良反应总发生率为10.6%,对照组为12.1%,两组比较差异无统计学意义(P>0.05)。结论多索茶碱联合舒利迭治疗小儿支气管哮喘临床效果好,改善患儿临床症状及肺功能更明显,临床总有效率更高,并且没有增加不良反应发生,值得临床推广应用。Objective To study the clinical effect of doxofylline combined with seretide in the treatment of children bronchial asthma to provide more solutions for its clinical treatment.Methods 132 cases of children bronchial asthma in our hospital from February 2012 to February 2014 were selected and randomly divided into the control group and the experiment group,66 cases in each group.The control group was given only seretide,while the experiment group adopted the treatment of doxofylline combined with Seretide.Results The disappearance time of symptoms of such as cough,wheezing,pulmonary rales and wheezing after treatment in the experiment group was significantly less than that in the control group,the difference between two groups was statistically significant（P〈0.05）;FEV1,FVC and VC levels after the treatment in the two groups were significantly increased,moreover the increase in the treatment group was more significant,the difference between two groups was statistically significant（P〈0.05）;the clinical total effective rate after treatment in the experiment group was 93.9%,which was significantly higher than 78.8%in the control group with statistical difference（P〈0.05）;the occurrence rate of adverse reactions was10.6%in the experiment group and 12.1%in the control group without statistically significant difference between the two groups（P〉0.05）.Conclusion Doxofylline combined with seretide has significant effect for treating bronchial asthma in children,the improvement of the clinical symptoms and lung function is more obvious and the total clinical efficiency is higher without increasing the occurrence of adverse reactions,it is worthy of clinical promotion and application.

关 键 词：多索茶碱 舒利迭 支气管哮喘 临床观察 

分 类 号：R725.6[医药卫生—儿科]