基于多水平模型的老年抑郁与认知损害关系纵向研究  

Longitudinal study of relationship between depression and cognitive impairment among elderly based on multilevel model

作　　者：陈旺生[1] 宋平平[2] 余红梅[2] 

机构地区：[1]山西省卫生厅卫生监督所,山西太原030045 [2]山西医科大学公共卫生学院,030001

出　　处：《中国公共卫生管理》2015年第3期284-286,共3页Chinese Journal of Public Health Management

基　　金：国家自然科学基金(81373106);山西省科技攻关项目(20140313017-6)

摘　　要：目的主要探讨认知损害对老年抑郁的影响,同时了解老年抑郁进展的影响因素。方法 2010年10月-2011年12月,采取问卷调查方式对太原市517名65岁及以上老年人群每6个月随访一次,以反映抑郁程度的老年抑郁量表(The Geriatric Depression Scale,GDS)得分为反应变量,第1个水平的观察单位是时间,第2个水平是个体,拟合重复测量资料的多水平模型,分析认知损害及其他因素对老年抑郁的影响。结果多水平模型分析结果表明控制个体背景协变量后,认知损害组平均初始GDS分值高于非认知损害组(t=2.09,P=0.038),且GDS平均分值随时间增长速率更快(t=2.56,P=0.011)。离退休前职业、目前经济来源、生活居住情况、看书读报、铝制炊具使用频率、糖尿病、心脏病等对老年抑郁的影响也有统计学意义。结论老年认知损害与老年抑郁的发生发展有关,老年抑郁也与社会人口学变量、生活方式和慢性病有关。Objective To explore the impact of cognitive impairment on depression among the elderly and to investigate the influential factors of depression progression at the same time. Methods Five hundred and seventeen older adults（≥65 years old） in Taiyuan were followed every six months from October 2010 to December 2011. Questionnaire survey was applied to collect the information. The Geriatric Depression Scale scores were treated as dependent variables. The multilevel model for repeated measurement data was fitted with level 1 unit and level 2 unit representing time and individual respectively to explore impact about cognitive impairment and other factors to depression. Results The results of multilevel model analysis showed that after controlling individual background covariates, the average baseline GDS scores of cognitive impairment group were higher than non-cognitive impairment group（t=2.09,P=0.038）, and accumulate rate of GDS scores for cognitive impairment group was greater than non-cognitive impairment group（t =2.56,P =0.011）. Former occupation, source of income, living, reading books or newspapers, use of pots and pans made of aluminum, diabetes, heart disease were also statistically significant. Conclusion Depression is associated with cognitive impairment among the elderly and it is also related to social demography variables, lifestyle and chronic diseases.

关 键 词：认知损害 抑郁 重复测量资料 多水平模型 

分 类 号：R195[医药卫生—卫生统计学]