左西孟旦治疗脓毒症休克并心肌抑制的临床疗效观察  

The Clinical Effects of Levosimendan in Treatment of Septic Shock and Cardiac Depression

作　　者：黄河[1] 孙小聪[1] 麦晓勤 佟琳[1] 胡桂芳[1] 

机构地区：[1]广东医学院附属医院,广东湛江524000

出　　处：《四川医学》2015年第6期831-834,共4页Sichuan Medical Journal

摘　　要：目的探讨左西孟旦对脓毒症休克并心肌抑制的临床治疗效果。方法将51例脓毒症休克合并心肌抑制患者随机分成治疗组和对照组,对照组在基础治疗上加米力农治疗,治疗组在基础治疗上加左西盂旦治疗。观察两组患者的治疗效果。结果与对照组比较,治疗组治疗后SVI、CI、LVSWI升高更明显,差异有统计学意义(P<0.05),HR、Lac、NT-pro BNP、EVLWI下降更明显,差异有统计学意义(P<0.05)。对照组治疗后SVRI升高较治疗组明显。治疗组机械通气时间、ICU住院时间较对照组明显缩短,差异有统计学意义(P<0.05),两组患者住院病死率差异无统计学意义(P>0.05)。结论左西孟旦可以改善脓毒症休克并心肌抑制患者的心功能,降低血管外肺水,提高组织灌注及氧代谢、减少机械通气时间,缩短ICU住院时间。Objective To investigate the clinical effect of levosimendan on septic shock and myocardial depression. Methods 51 cases of septic shock with myocardial depression patients were randomly divided into treatment group and control group. The control group received Milrinone treatment on the basis of the treatment. Treatment group received levosimendan treat-ment on the basis of the treatment. To observe the therapeutic effect of two groups of patients. Results Compared with the control group,after the treatment in the treatment group,SVI,CI,LVSWI were significantly increased（P〈0. 05）,HR,Lac,NT-proBNP, EVLWI were significantly decreased（P〈0. 05）. Compared with the treatment group,after the treatment in the control group,SVRI was significantly increased（P〈0. 05）. Compared with the control group,in the treatment group,the mechanical ventilation time and the length of stay in ICU,were significantly shorter（P〈0. 05）,the two groups showed no significant difference in hospital mor-tality（P〉0. 05）. Conclusion levosimendan can improve heart function,reduce extravascular lung water,improve tissue perfu-sion and oxygen metabolism,reduce mechanical ventilation time,shorten the length of stay in ICU of patients with septic shock and cardiac depression.

关 键 词：左西孟旦 脓毒症休克 心肌抑制 脉波指示剂连续心排血量监测 

分 类 号：R459.7[医药卫生—急诊医学]