体外冲击波碎石术后应用坦索罗辛治疗单发肾结石疗效的系统评价  

Efficacy of tamsulosin for single renal stone after extracorporeal shock wave lithotripsy: a systematic review

作　　者：胡潇[1] 陆洪兵[1] 崔飞伦[1] 秦超[2] 

机构地区：[1]镇江市第一人民医院泌尿外科,江苏省212002 [2]南京医科大学第一附属医院泌尿外科,210029

出　　处：《中华临床医师杂志（电子版）》2015年第11期130-133,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81201571)

摘　　要：目的对体外冲击波碎石术后应用坦索罗辛治疗单发肾结石的疗效进行系统评价。方法检索Pub Med,Embase和Cochrane图书馆,纳入体外冲击波碎石术后使用坦索罗辛治疗单发肾结石的随机对照试验。对纳入文献进行方法学质量评估,观察指标为碎石清除率和平均排出时间。结果纳入的7个随机对照试验共评估了866例患者,Meta分析提示与空白/安慰剂组比较,坦索罗辛能够显著提高单发肾结石患者在体外冲击波碎石术后4周[RR=1.59,95%CI(1.19,2.14)]和12周[RR=1.17,95%CI(1.04,1.31)]的碎石清除率。结论与空白/安慰剂组相比,在体外冲击波碎石术后使用0.4 mg/d坦索罗辛有可能显著提高肾结石患者的碎石清除率,仍需要更多高质量的大样本随机对照试验。Objective To assess the efficacy of tamsulosin for patients with single renal stone after extracorporeal shock wave lithotripsy （ESWL）. Methods Databases including Pubmed, Embase and Cochrane Library were searched and randomized controlled trials in which tamsulosin were evaluated for single renal stone aRer ESWL were included. Methodological quality was evaluated for each included study and stone clearance rate and mean expulsion time were assessed. Results Seven randomized controlled trials with low methodological quality and 866 patients in total were included. The results of Meta-aualysis showed that compared with the blank or placebo group tamsulosin could increase significantly the stone clearance rate for the single renal stone after ESWL at 4 weeks, RR=1.59, 95% confidence interval （1.19, 2.14）, and 12 weeks, RR=1.17, 95% confidence interval （1.04, 1.31）. Conclusion Compared with blank or placebo group, treatment with tamsulosin 0.4 mg daily aRer ESWL appears to be effective in assisting stone clearance in patients with single renal calculi. Further more randomized controlled trials with high quality and large samples are encouraged.

关 键 词：肾结石 单发 体外冲击波碎石术 坦索罗辛 系统评价 

分 类 号：R699.2[医药卫生—泌尿科学]